| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Pancreatic primitive neuroectodermal tumors: Clinical features, treatment, and influencing factors
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yan-Fei He, Huan-Zhi Wang, Xiao-Dong Hu, Jun-Qiang Liu, Hu-Ming Li, Jie Wang and Shuang-Feng Lu |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Yan-Fei He, MD, Associate Chief Physician, Health Management Center, The Sixth Medical Center, Chinese PLA General Hospital, No. 6 Fu Cheng Road, HaiDian District, Beijing 100048, China. heyanfeilc@163.com |
| Key Words |
Primitive neuroectodermal tumor; Pancreas; Sarcoma; Diagnosis; Prognosis; Treatment |
| Core Tip |
Pancreatic primitive neuroectodermal tumor (PNET) is a rare disease, and its rarity has hindered the establishment of sound treatment strategies and prognostic data. We searched global databases for a total of 30 cases of pancreatic PNET published in English and Chinese from around the world and retrospectively analyzed their demographic data, clinical characteristics, and treatment factors. Univariate analysis and Cox regression analysis were used to determine the prognostic factors associated with survival. Our study showed that the mean age of all patients was 24 years, the median survival time was 41.0 months, and the overall estimated 1- and 3-year survival rates were approximately 66.0% and 36.4%, respectively. Univariate analysis showed that surgical margins (P = 0.048), chemotherapy (P = 0.036), local metastasis (P = 0.041), lymph node metastasis (P = 0.003), and distant metastasis (P = 0.049) were the prognostic factors affecting survival. Multivariate analysis revealed that only lymph node metastasis (P = 0.012) was a significant prognostic factor. The results of this study suggest that early diagnosis of pancreatic PNET is critical, and early wide resection and adjuvant radiotherapy may help to improve prognosis. Our study provides new information on survival data for this rare disease and has significant clinical value. |
| Publish Date |
2025-01-18 08:11 |
| Citation |
<p>He YF, Wang HZ, Hu XD, Liu JQ, Li HM, Wang J, Lu SF. Pancreatic primitive neuroectodermal tumors: Clinical features, treatment, and influencing factors. <i>World J Gastrointest Oncol</i> 2025; 17(2): 97298</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i2/97298.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i2.97298 |
