Publication Name	World Journal of Diabetes
Manuscript ID	97315
Country	Mexico

Received	2024-05-27 21:59
Peer-Review Started	2024-05-27 21:59
To Make the First Decision
Return for Revision	2024-06-20 04:58
Revised	2024-06-29 05:28
Second Decision	2024-07-19 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-19 06:12
Articles in Press	2024-07-19 06:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-07-28 14:20
Publish the Manuscript Online	2024-09-26 08:51

ISSN	1948-9358 (online)
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Category	Biochemistry & Molecular Biology
Manuscript Type	Editorial
Article Title	Don´t give up on mitochondria as a target for the treatment of diabetes and its complications
Manuscript Source	Invited Manuscript
All Author List	Christian Cortés-Rojo and Manuel Alejandro Vargas-Vargas
ORCID	Author(s) ORCID Number Christian Cortés-Rojo http://orcid.org/0000-0002-4850-772X Manuel Alejandro Vargas-Vargas http://orcid.org/0000-0003-3239-123X
Funding Agency and Grant Number	Funding Agency Grant Number Instituto de Ciencia, Tecnología e Innovación - Gobierno del Estado de Michoacán, México ICTI-PICIR23-063 Programa Proyectos de Investigación Financiados 2024, Coordinación de Investigación Científica, Universidad Michoacana de San Nicolás de Hidalgo, México
Corresponding Author	Christian Cortés-Rojo, BSc, MSc, PhD, Professor, Instituto de Investigaciones Químico - Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-3, Ciudad Universitaria, Avenida Fco J Mujica, Morelia 58030, Michoacán, Mexico. christian.cortes@umich.mx
Key Words	Diabetes mellitus; Insulin resistance; Mitochondrion; Mitochondrial dysfunction; MitoQ; MitoTEMPO; SkQ; Elamipretide; Mitochondria transplantation; Glycemic control
Core Tip	Mitochondrial dysfunction and oxidative stress are closely linked to the development of diabetes and its complications. This has motivated the targeting of antioxidants to the mitochondria for diabetes treatment, which has generated in pre-clinical trials some encouraging results in diabetic complications, but inconsistent results in glycemic control. Moreover, there are very few studies with these molecules and only in healthy patients, with no encouraging results. There are several challenges to overcome to make mitochondria an efficient pharmacological target against diabetes, but recent developments such as mitochondrial transplantation, bioactive small peptides, and atomistic simulations could help to achieve this goal.
Publish Date	2024-09-26 08:51
Citation	<p>Cortés-Rojo C, Vargas-Vargas MA. Don´t give up on mitochondria as a target for the treatment of diabetes and its complications. <i>World J Diabetes</i> 2024; 15(10): 2015-2021</p>
URL	https://www.wjgnet.com/1948-9358/full/v15/i10/2015.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i10.2015

Full Article (PDF)	WJD-15-2015-with-cover.pdf
Manuscript File	97315_Auto_Edited_065555.docx
Answering Reviewers	97315-answering-reviewers.pdf
Audio Core Tip	97315-audio.mp3
Conflict-of-Interest Disclosure Form	97315-conflict-of-interest-statement.pdf
Copyright License Agreement	97315-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	97315-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	97315-non-native-speakers.pdf
Peer-review Report	97315-peer-reviews.pdf
Scientific Misconduct Check	97315-scientific-misconduct-check.png
Scientific Editor Work List	97315-scientific-editor-work-list.pdf
CrossCheck Report	97315-crosscheck-report.png
CrossCheck Report	97315-crosscheck-report.pdf