Publication Name	World Journal of Experimental Medicine
Manuscript ID	97404
Country	Bulgaria

Received	2024-08-19 07:39
Peer-Review Started	2024-05-30 03:28
To Make the First Decision
Return for Revision	2024-09-25 13:45
Revised	2024-10-09 00:44
Second Decision	2024-11-14 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-14 09:17
Articles in Press	2024-11-14 09:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-11-25 00:50
Typeset the Manuscript	2024-11-28 08:31
Publish the Manuscript Online	2024-12-26 03:04

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Genetic factors that predict response and failure of biologic therapy in Inflammatory Bowel Disease
Manuscript Source	Invited Manuscript
All Author List	Milena Peruhova, Daniela Stoyanova, Dimitrina Georgieva Miteva, Meglena Kitanova, Milko Bozhidarov Mirchev and Tsvetelina Velikova
ORCID	Author(s) ORCID Number Daniela Stoyanova http://orcid.org/0000-0002-2288-1596 Milko Bozhidarov Mirchev http://orcid.org/0000-0002-9315-7650
Funding Agency and Grant Number	Funding Agency Grant Number The European Union-Next Generation EU, through the National Recovery and Resilience Plan of the Republic of Bulgaria No. BG-RRP-2.004-0008
Corresponding Author	Daniela Stoyanova, MD, Department of Gastroenterology, Military Medical Academy, Georgy Sofiysky Street 3, Sofia 1606, Bulgaria. d.stoyanova@mail.bg
Key Words	Inflammatory bowel disease; Genetic predictors; Inflammatory bowel disease treatment; Biologic therapy; Biologic therapy response; Genetic markers in inflammatory bowel disease; Inflammatory bowel disease treatment failure; Pharmacogenomics; Biologic therapy efficacy; Genetic variability
Core Tip	Understanding the genetic factors that influence the response and failure of biological therapy in Inflammatory Bowel Disease (IBD) is crucial for optimizing treatment strategies. Identifying specific genetic markers can help predict patient outcomes, tailor personalized therapies, and improve efficacy while minimizing adverse effects. This approach enhances clinical decision-making, leading to better management of IBD and improved patient quality of life. Future research should focus on expanding genetic profiling to refine therapeutic interventions.
Publish Date	2024-12-26 03:04
Citation	<p>Peruhova M, Stoyanova D, Miteva DG, Kitanova M, Mirchev MB, Velikova T. Genetic factors that predict response and failure of biologic therapy in Inflammatory Bowel Disease. <i>World J Exp Med</i> 2025; 15(1): 97404</p>
URL	https://www.wjgnet.com/2220-315x/full/v15/i1/97404.htm
DOI	https://dx.doi.org/10.5493/wjem.v15.i1.97404

Full Article (PDF)	WJEM-15-97404-with-cover.pdf
Manuscript File	97404_Auto_Edited_103022.docx
Answering Reviewers	97404-answering-reviewers.pdf
Audio Core Tip	97404-audio.mp3
Conflict-of-Interest Disclosure Form	97404-conflict-of-interest-statement.pdf
Copyright License Agreement	97404-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	97404-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	97404-non-native-speakers.pdf
Peer-review Report	97404-peer-reviews.pdf
Scientific Misconduct Check	97404-scientific-misconduct-check.png
Scientific Editor Work List	97404-scientific-editor-work-list.pdf
CrossCheck Report	97404-crosscheck-report.pdf