Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	97448
Country	China

Received	2024-05-30 13:33
Peer-Review Started	2024-05-30 13:33
To Make the First Decision
Return for Revision	2024-09-10 01:53
Revised	2024-09-22 19:35
Second Decision	2024-10-08 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-08 07:35
Articles in Press	2024-10-08 07:35
Publication Fee Transferred	2024-10-10 09:52
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-29 14:39
Publish the Manuscript Online	2024-11-12 12:23

ISSN	1948-5204 (online)
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Prognosis of radiotherapy for esophageal cancer in elderly patients exceeding seventy-five years old
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Li Hu, Feng Rong, Lei Liu, Ling Zhang, Lei-Lei Zhang, Qun Yang, Zhao-Long Xia and Hui Wang
ORCID	Author(s) ORCID Number Li-Li Hu http://orcid.org/0009-0002-3920-5057 Feng Rong http://orcid.org/0000-0001-7827-6347 Lei Liu http://orcid.org/0009-0009-3348-4965 Ling Zhang http://orcid.org/0009-0008-8937-2578 Lei-Lei Zhang http://orcid.org/0009-0000-7662-7924 Zhao-Long Xia http://orcid.org/0009-0006-7820-1365 Hui Wang http://orcid.org/0000-0001-5503-0547
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Program of Lu’an No. 2022 Lakj042
Corresponding Author	Hui Wang, MD, PhD, Doctor, Doctor, Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Hefei Economic Development Zone, Hefei 230601, Anhui Province, China. 1223556508@qq.com
Key Words	Elderly patient; Esophageal cancer; Radiotherapy; Prognosis; Comorbidity; Nutritional risk
Core Tip	Esophageal cancer (EC) often occurs in the elderly, with approximately 33% of patients aged ≥ 75 years at the time of diagnosis. Since patients aged 75 years and above are often excluded from many clinical trials of EC, there is a lack of agreement regarding the prognosis and treatment of this population. We retrospectively analyzed the clinical characteristics, toxic reactions, and survival information of elderly patients with EC aged ≥ 75 years who received intensity-modulated radiotherapy. Our analysis aimed to evaluate the prognostic factors affecting overall survival. We found that the Charlson comorbidity index and nutritional risk screening 2002 were independent prognostic factors for overall survival. Our results suggest that when formulating treatment plans for elderly patients with EC, full attention should be given to age-related biological indicators such as comorbidities and nutrition.
Publish Date	2024-11-12 12:23
Citation	<p>Hu LL, Rong F, Liu L, Zhang L, Zhang LL, Yang Q, Xia ZL, Wang H. Prognosis of radiotherapy for esophageal cancer in elderly patients exceeding seventy-five years old. <i>World J Gastrointest Oncol</i> 2024; 16(12): 4636-4649</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i12/4636.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i12.4636

Full Article (PDF)	WJGO-16-4636-with-cover.pdf
Manuscript File	97448_Auto_Edited_073411.docx
Answering Reviewers	97448-answering-reviewers.pdf
Audio Core Tip	97448-audio.mp3
Biostatistics Review Certificate	97448-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	97448-conflict-of-interest-statement.pdf
Copyright License Agreement	97448-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	97448-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	97448-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	97448-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	97448-non-native-speakers.pdf
Peer-review Report	97448-peer-reviews.pdf
Scientific Misconduct Check	97448-scientific-misconduct-check.png
Scientific Editor Work List	97448-scientific-editor-work-list.pdf
CrossCheck Report	97448-crosscheck-report.png
CrossCheck Report	97448-crosscheck-report.pdf