Publication Name	World Journal of Hepatology
Manuscript ID	97523
Country	China

Received	2024-06-02 02:58
Peer-Review Started	2024-06-02 02:58
To Make the First Decision
Return for Revision	2024-07-10 04:52
Revised	2024-07-24 04:20
Second Decision	2024-08-02 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-08-02 09:18
Articles in Press	2024-08-02 09:18
Publication Fee Transferred	2024-08-02 13:27
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-08-13 00:22
Publish the Manuscript Online	2024-08-21 23:22

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical and Translational Research
Article Title	Causal association between 731 immunocyte phenotypes and liver cirrhosis: A bidirectional two-sample mendelian randomization analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Ying Li, Xin Quan, Yang Tai, Yu-Tong Wu, Bo Wei and Hao Wu
ORCID	Author(s) ORCID Number Ying Li http://orcid.org/0009-0009-0895-5913 Yang Tai http://orcid.org/0000-0001-8847-5075 Hao Wu http://orcid.org/0000-0001-6751-3036
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82270649
Corresponding Author	Hao Wu, PhD, Doctor, Doctor, Professor, Department of Gastroenterology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, China. hxxhwh@163.com
Key Words	Liver cirrhosis; Immune cell; Immunocyte phenotype; Mendelian analysis; Causal association
Core Tip	The causal relationship between immunocyte phenotypes and liver cirrhosis has not been fully elucidated. This bidirectional two-sample mendelian randomization study identified a significant causal association between 731 immunocyte phenotypes and liver cirrhosis. We found that 20 immunocyte phenotypes were associated with liver cirrhosis (P < 0.05), whereas liver cirrhosis was associated with 19 immunocyte phenotypes (P < 0.05). None of these associations showed heterogeneity or horizontal pleiotropy (P > 0.05). These findings provide novel directions for the treatment of liver cirrhosis.
Publish Date	2024-08-21 23:22
Citation	<p>Li Y, Quan X, Tai Y, Wu YT, Wei B, Wu H. Causal association between 731 immunocyte phenotypes and liver cirrhosis: A bidirectional two-sample mendelian randomization analysis. <i>World J Hepatol</i> 2024; 16(8): 1156-1166</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i8/1156.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i8.1156

Full Article (PDF)	WJH-16-1156-with-cover.pdf
Manuscript File	97523_Auto_Edited_062432.docx
Answering Reviewers	97523-answering-reviewers.pdf
Audio Core Tip	97523-audio.mp3
Biostatistics Review Certificate	97523-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	97523-conflict-of-interest-statement.pdf
Copyright License Agreement	97523-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	97523-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	97523-non-native-speakers.pdf
Supplementary Material	97523-supplementary-material.pdf
Peer-review Report	97523-peer-reviews.pdf
Scientific Misconduct Check	97523-scientific-misconduct-check.png
Scientific Editor Work List	97523-scientific-editor-work-list.pdf
CrossCheck Report	97523-crosscheck-report.png
CrossCheck Report	97523-crosscheck-report.pdf