Publication Name	World Journal of Gastroenterology
Manuscript ID	9761
Country	France

Received	2014-02-27 09:14
Peer-Review Started	2014-02-27 10:47
To Make the First Decision	2014-03-27 21:06
Return for Revision	2014-03-31 10:15
Revised	2014-04-18 00:00
Second Decision	2014-05-26 21:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-26 21:54
Articles in Press	2014-05-26 22:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-27 17:34
Publish the Manuscript Online	2014-09-18 19:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Infectious etiopathogenesis of Crohn’s disease
Manuscript Source	Invited Manuscript
All Author List	Jessica Carrière, Arlette Darfeuille-Michaud and Hang Thi Thu Nguyen
Funding Agency and Grant Number	Funding Agency Grant Number Ministère de la Recherche et de la Technologie, Inserm UMR1071 INRA USC-2018 Association François Aupetit to Darfeuille-Michaud A European Union FP7 People Marie Curie International Incoming Fellowship to Nguyen HTT
Corresponding Author	Hang Thi Thu Nguyen, PhD, Clermont Université, M2iSH, UMR 1071 Inserm/University of Auvergne, 28 Place Henri Dunant, 63001 Clermont-Ferrand, France. hang.nguyen@udamail.fr
Key Words	Crohn’s disease; Intestinal microbiota; Dysbiosis; Adherent-invasive Escherichia coli; Probiotics; Antibiotics; Fecal microbiota transplantation
Core Tip	Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract of which the etiopathogenesis is not fully understood. Increasing evidence has shown that the etiology of CD is multifactorial involving genetic, environmental and infectious factors. A dysbiosis with an increase in the abundance of putative pathogenic bacteria and a decrease in that of potentially beneficial bacteria has been observed in CD patients, revealing the involvement of intestinal microbiota in such disease. This review aims to summarize the current knowledge of the infectious etiology of CD and to discuss therapeutic approaches to modulate intestinal dysbiosis and to target CD-associated pathogens.
Publish Date	2014-09-18 19:50
Citation	Carrière J, Darfeuille-Michaud A, Nguyen HTT. Infectious etiopathogenesis of Crohn's disease. World J Gastroenterol 2014; 20(34): 12102-12117
URL	http://www.wjgnet.com/1007-9327/full/v20/i34/12102.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i34.12102

Full Article (PDF)	WJG-20-12102.pdf
Full Article (Word)	WJG-20-12102.doc
Manuscript File	9761-Review.doc
Answering Reviewers	9761-Answer reviewers.pdf
Copyright License Agreement	9761-Copyright Assignment.pdf
Peer-review Report	9761-Peer review.pdf
Scientific Misconduct Check	9761-CrossCheck.jpg
Scientific Editor Work List	9761-Scientific editor work list.pdf