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2/10/2025 7:51:19 AM | Browse: 71 | Download: 439
Publication Name World Journal of Clinical Cases
Manuscript ID 97716
Country Greece
Received
2024-06-05 20:25
Peer-Review Started
2024-06-05 20:25
First Decision by Editorial Office Director
2024-08-13 22:49
Return for Revision
2024-08-13 22:49
Revised
2024-09-04 21:43
Publication Fee Transferred
2024-12-19 08:11
Second Decision by Editor
2024-09-23 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2024-09-23 11:06
Articles in Press
2024-09-23 11:06
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-01-15 00:53
Publish the Manuscript Online
2025-02-10 07:51
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Clinical Neurology
Manuscript Type Case Report
Article Title Gamma-aminobutiric acid-B receptor antibody-related limbic encephalitis due to small cell lung carcinoma: Two case reports
Manuscript Source Unsolicited Manuscript
All Author List Athena D Myrou, Martha G Spilioti, Anthoula C Tsolaki, Antonis N Frontistis and Christos G Savopoulos
ORCID
Author(s) ORCID Number
Athena D Myrou http://orcid.org/0000-0002-2629-1841
Martha G Spilioti http://orcid.org/0000-0002-9035-3963
Anthoula C Tsolaki http://orcid.org/0000-0002-5536-7776
Antonis N Frontistis http://orcid.org/0000-0003-2666-8183
Christos G Savopoulos http://orcid.org/0000-0002-7970-2464
Funding Agency and Grant Number
Corresponding Author Athena D Myrou, Doctor, MD, MSc, PhD, Consultant Physician-Scientist, Department of Internal Medicine, AHEPA University General Hospital, St Kyriakidi 1 street, Thessaloniki 54636, Greece. taniamyrou@gmail.com
Key Words Gamma aminobutyric acid-B receptor antibody; Paraneoplastic encephalitis; Small cell lung carcinoma; Epileptic seizures; Limbic encephalitis; Case report
Core Tip Limbic encephalitis (LE) can occur as a paraneoplastic symptom or in the absence of a malignancy. Paraneoplastic encephalopathies are rare neurological disorders associated with antineuronal antibodies. Symptoms include memory loss, impaired mental function, behavioral disorders, and epileptic seizures. Antibodies against extracellular antigens, such as gamma-aminobutyric acid (GABA) B receptor (GABABR), are associated with a higher risk of tumor development. Glutamic acid decarboxylase antibodies have been linked to several neurological syndromes, which are hypothesized to result from decreased GABA ergic transmission. This article presents two cases of GABABR antibody-related LE resulting from small cell lung carcinoma with neurological symptoms that were managed with intravenous immunoglobulin therapy.
Publish Date 2025-02-10 07:51
Citation

Myrou AD, Spilioti MG, Tsolaki AC, Frontistis AN, Savopoulos CG. Gamma-aminobutiric acid-B receptor antibody-related limbic encephalitis due to small cell lung carcinoma: Two case reports. World J Clin Cases 2025; 13(16): 97716

URL https://www.wjgnet.com/2307-8960/full/v13/i16/97716.htm
DOI https://dx.doi.org/10.12998/wjcc.v13.i16.97716
Full Article (PDF) WJCC-13-97716-with-cover.pdf
CARE Checklist–2016 97716-CARE-Checklist-2016.pdf
Manuscript File 97716_Auto_Edited_083327.docx
Answering Reviewers 97716-answering-reviewers.pdf
Audio Core Tip 97716-audio.mp4
Conflict-of-Interest Disclosure Form 97716-conflict-of-interest-statement.pdf
Copyright License Agreement 97716-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s) 97716-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate 97716-non-native-speakers.pdf
Peer-review Report 97716-peer-reviews.pdf
Scientific Misconduct Check 97716-scientific-misconduct-check.png
Scientific Editor Work List 97716-scientific-editor-work-list.pdf
CrossCheck Report 97716-crosscheck-report.pdf