Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	97720
Country	China

Received	2024-08-01 08:56
Peer-Review Started	2024-08-01 08:56
To Make the First Decision
Return for Revision	2024-08-21 10:12
Revised	2024-08-30 04:19
Second Decision	2024-09-03 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-03 08:26
Articles in Press	2024-09-03 08:26
Publication Fee Transferred	2024-09-04 00:36
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-18 23:41
Publish the Manuscript Online	2024-09-28 04:34

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Effects of postoperative treatment with chemotherapy and cellular immunotherapy on patients with colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Zhen-Yu Ding, Ying Piao, Tong Jiang, Juan Chen, Yi-Nuo Wang, Hui-Ying Yu and Zhen-Dong Zheng
ORCID	Author(s) ORCID Number Zhen-Dong Zheng http://orcid.org/0009-0002-5517-5185
Funding Agency and Grant Number
Corresponding Author	Zhen-Dong Zheng, PhD, Chief Physician, Department of Oncology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenyang 110016, Liaoning Province, China. zzd_oncologist@163.com
Key Words	Analysis of variables affecting outcomes; Cellular immunotherapy; Chemotherapy; Colorectal cancer; Clinical effects
Core Tip	Adjuvant postoperative therapy for colorectal cancer (CRC) maximizes surgical outcomes while significantly reducing CRC-related mortality. This study analyzes the efficacy of the XELOX regimen combined with dendritic cell-cytokine-induced killer (DC-CIK) cell immunotherapy for postoperative CRC patients and the mediating variables, aiming to provide a useful clinical reference to optimize the efficacy of postoperative CRC treatment. Through a comparative analysis of the XELOX chemotherapy regimen vs XELOX regimen plus DC-CIK immunotherapy therapy across multiple outcome and safety indices, including efficacy, adverse event rates, serum tumor marker levels, and T-cell subset levels, the combination regimen is confirmed to offer greater efficacy than a chemotherapy regimen alone, enhancing patient immunity, increasing physiological antitumor activity, and providing improved treatment safety.
Publish Date	2024-09-28 04:34
Citation	<p>Ding ZY, Piao Y, Jiang T, Chen J, Wang YN, Yu HY, Zheng ZD. Effects of postoperative treatment with chemotherapy and cellular immunotherapy on patients with colorectal cancer. <i>World J Gastrointest Surg</i> 2024; 16(10): 3202-3210</p>
URL	https://www.wjgnet.com/1948-9366/full/v16/i10/3202.htm
DOI	https://dx.doi.org/10.4240/wjgs.v16.i10.3202

Full Article (PDF)	WJGS-16-3202-with-cover.pdf
Manuscript File	97720_Auto_Edited_033640.docx
Answering Reviewers	97720-answering-reviewers.pdf
Audio Core Tip	97720-audio.mp3
Biostatistics Review Certificate	97720-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	97720-conflict-of-interest-statement.pdf
Copyright License Agreement	97720-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	97720-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	97720-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	97720-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	97720-non-native-speakers.pdf
Peer-review Report	97720-peer-reviews.pdf
Scientific Editor Work List	97720-scientific-editor-work-list.pdf
Scientific Editor Work List	97720-scientific-editor-work-list.png
CrossCheck Report	97720-crosscheck-report.png
CrossCheck Report	97720-crosscheck-report.pdf