| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Plasma DNA methylation detection for early screening, diagnosis, and monitoring of esophageal adenocarcinoma and squamous cell carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xu-Ji Liu, Guo-Liang Pi, Sheng Wang, Jin-Dan Kai, Hui-Fang Yu, Hong-Wei Shi, Jing Yu and Hui Zeng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Medical Talents of Wuhan Hospital of Traditional Chinese and Western Medicine |
202212001 |
| Hubei Natural Science Foundation |
2023AFB1091 |
| Hubei Natural Science Foundation |
2023AFB988 |
| The Research Projects of Biomedical Center of Hubei Cancer Hospital |
2022SWZX19 |
| The 7th Wuhan Young and Middle-Aged Backbone Talent of Medical Training Project |
2019-87 |
|
| Corresponding Author |
Jing Yu, PhD, Doctor, Doctor, Department of Laboratory, Wuhan Hospital of Traditional Chinese and Western Medicine, Tongji Medical College, Huazhong University of Science and Technology, No.215 Zhongshan Road, Wuhan 430022, Hubei Province, China. yujings9774@sina.com.cn |
| Key Words |
Methylation; Tumor markers; Esophageal squamous cell carcinoma; Adenocarcinoma; Diagnosis |
| Core Tip |
This study first analyzed the clinical diagnosis and monitoring value of detecting plasma SHOX2, SEPTIN9, EPO, and RNF180 methylation for esophageal cancer (EC). We revealed sensitivity and specificity of the four DNA plasma methylations exhibited 76.19% sensitivity and 86.27% specificity for detecting EC. And the area under the curve value for this combination was 0.864 (0.809–0.92). The accurate measurement of these four DNA plasma methylations might aid monitoring of therapy efficacy in both Esophageal Adenocarcinoma and Squamous Cell Carcinoma. |
| Publish Date |
2024-10-31 10:42 |
| Citation |
<p>Liu XJ, Pi GL, Wang S, Kai JD, Yu HF, Shi HW, Yu J, Zeng H. Plasma DNA methylation detection for early screening, diagnosis, and monitoring of esophageal adenocarcinoma and squamous cell carcinoma. <i>World J Gastroenterol</i> 2024; 30(43): 4609-4619</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i43/4609.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i43.4609 |
