Publication Name	World Journal of Orthopedics
Manuscript ID	97848
Country	United States

Received	2024-06-10 22:37
Peer-Review Started	2024-06-10 22:37
To Make the First Decision
Return for Revision	2024-10-14 02:48
Revised	2024-10-28 02:42
Second Decision	2024-12-25 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-25 10:21
Articles in Press	2024-12-25 10:21
Publication Fee Transferred	2024-11-06 14:57
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-08 02:17
Publish the Manuscript Online	2025-01-13 08:26

ISSN	2218-5836 (online)
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Category	Orthopedics
Manuscript Type	Systematic Reviews
Article Title	Limited evidence to support demineralized bone matrix in foot and ankle surgical procedures: A systematic review
Manuscript Source	Unsolicited Manuscript
All Author List	Hayden Hartman, James J Butler, Megan Calton, Charles C Lin, Samantha Rettig, Jared C Tishelman, Sebastian Krebsbach, Grace W Randall and John G Kennedy
ORCID	Author(s) ORCID Number John G Kennedy http://orcid.org/0000-0002-7286-0689
Funding Agency and Grant Number
Corresponding Author	John G Kennedy, MD, Professor, Department of Orthopedic Surgery, NYU Langone Health, 171 Delancey Street, New York, NY 10002, United States. john.kennedy@nyulangone.org
Key Words	Demineralized bone matrix; Allogenic bone graft; osseous union; Biological adjunct; Systematic review; Bone morphogenetic proteins; Lower limb fusion; Arthrodesis
Core Tip	Despite the prevalent use of demineralized bone matrix in foot and ankle surgeries, this systematic review uncovers a lack of robust evidence supporting its efficacy. While it demonstrates satisfactory osseous union rates and favorable complication profiles, the insufficiency of high-quality studies and significant heterogeneity across research call for caution in its clinical application, emphasizing the need for further well-designed investigations to establish its effectiveness definitively.
Publish Date	2025-01-13 08:26
Citation	<p>Hartman H, Butler JJ, Calton M, Lin CC, Rettig S, Tishelman JC, Krebsbach S, Randall GW, Kennedy JG. Limited evidence to support demineralized bone matrix in foot and ankle surgical procedures: A systematic review. <i>World J Orthop</i> 2025; 16(1): 97848</p>
URL	https://www.wjgnet.com/2218-5836/full/v16/i1/97848.htm
DOI	https://dx.doi.org/10.5312/wjo.v16.i1.97848

Full Article (PDF)	WJO-16-97848-with-cover.pdf
PRISMA 2009 Checklist	97848-PRISMA-2009-Checklist.pdf
Manuscript File	97848_Auto_Edited_023234.docx
Answering Reviewers	97848-answering-reviewers.pdf
Audio Core Tip	97848-audio.mp4
Biostatistics Review Certificate	97848-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	97848-conflict-of-interest-statement.pdf
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Peer-review Report	97848-peer-reviews.pdf
Scientific Misconduct Check	97848-scientific-misconduct-check.png
Scientific Editor Work List	97848-scientific-editor-work-list.pdf
CrossCheck Report	97848-crosscheck-report.pdf