Publication Name	World Journal of Clinical Cases
Manuscript ID	97856
Country	Japan

Received	2024-06-11 06:37
Peer-Review Started	2024-06-11 06:37
To Make the First Decision
Return for Revision	2024-10-22 01:29
Revised	2024-10-22 04:40
Second Decision	2024-10-28 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-28 11:11
Articles in Press	2024-10-28 11:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-31 09:36
Publish the Manuscript Online	2024-11-12 06:40

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Neurosciences
Manuscript Type	Letter to the Editor
Article Title	Application of virtual reality technology improves the functionality of brain networks in individuals experiencing pain
Manuscript Source	Invited Manuscript
All Author List	Takahiko Nagamine
ORCID	Author(s) ORCID Number Takahiko Nagamine http://orcid.org/0000-0002-0690-6271
Funding Agency and Grant Number
Corresponding Author	Takahiko Nagamine, MD, PhD, Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu 7470066, Yamaguchi, Japan. anagamine@yahoo.co.jp
Key Words	Virtual reality; Pain; Anxiety; Salience network; Default mode network
Core Tip	Recently, efforts have been made to reduce the discomfort associated with invasive medical procedures through the use of virtual reality (VR) technology. Furthermore, VR has been demonstrated to be an effective treatment for chronic pain, for which no effective treatment has been established. Visual input of positive images may effectively alter functional brain networks. Pain and anxiety may be reduced by decreasing activity in the salience network and by allowing the medial prefrontal cortex to establish strong connections with the default mode network. VR technology can change brain networks and reduce pain and anxiety.
Publish Date	2024-11-12 06:40
Citation	<p>Nagamine T. Application of virtual reality technology improves the functionality of brain networks in individuals experiencing pain. <i>World J Clin Cases</i> 2025; 13(3): 97856</p>
URL	https://www.wjgnet.com/2307-8960/full/v13/i3/97856.htm
DOI	https://dx.doi.org/10.12998/wjcc.v13.i3.97856

Full Article (PDF)	WJCC-13-97856-with-cover.pdf
Manuscript File	97856_Auto_Edited_065457.docx
Answering Reviewers	97856-answering-reviewers.pdf
Audio Core Tip	97856-audio.mp3
Conflict-of-Interest Disclosure Form	97856-conflict-of-interest-statement.pdf
Copyright License Agreement	97856-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	97856-non-native-speakers.pdf
Peer-review Report	97856-peer-reviews.pdf
Scientific Editor Work List	97856-scientific-editor-work-list.pdf
CrossCheck Report	97856-crosscheck-report.pdf