BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
1/18/2025 8:11:58 AM | Browse: 177 | Download: 746
 |
Received |
|
2024-06-11 07:50 |
|
Peer-Review Started |
|
2024-06-11 07:50 |
|
First Decision by Editorial Office Director |
|
2024-10-10 08:54 |
|
Return for Revision |
|
2024-10-10 08:54 |
|
Revised |
|
2024-10-29 14:36 |
|
Publication Fee Transferred |
|
2024-11-12 11:05 |
|
Second Decision by Editor |
|
2024-11-08 02:37 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2024-11-08 07:27 |
|
Articles in Press |
|
2024-11-08 07:27 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2024-11-19 03:33 |
|
Publish the Manuscript Online |
|
2025-01-18 08:11 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Long Wang, Qi Wu, Zong-Wen Zhang, Hui Zhang, Hui Jin, Xin-Liang Zhou, Jia-Yin Liu, Dan Li, Yan Liu and Zhi-Song Fan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of Hebei Province of China |
No. H2022206523 |
| Hebei Province Medical Science Research Project Plan |
No. 20230755 and No. 20240840 |
| Clinical Research Special Fund of Wu Jieping Medical Foundation, China |
No. 320.6750.2022-16-17 |
|
| Corresponding Author |
Zhi-Song Fan, Associate Chief Physician, Associate Professor, MD, PhD, Department of Oncology, The Fourth Hospital of Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang 050011, Hebei Province, China. fanzs@hebmu.edu.cn |
| Key Words |
Gastric cancer; Immunosuppressive receptor; Colony-stimulating factor 3; Colony-stimulating factor 3 receptor; Leukocyte immunoglobulin-like receptor B2; Angiopoietin-like protein 2; Human leukocyte antigen-G; Heterogeneous nuclear ribonucleoprotein H1 |
| Core Tip |
This study investigates the relationship between colony-stimulating factor 3 (CSF3)/colony-stimulating factor 3 receptor (CSF3R) and leukocyte immunoglobulin-like receptor B2, along with its ligands angiopoietin-like protein 2 and human leukocyte antigen-G, in gastric cancer (GC). High CSF3R expression correlates with increased levels of leukocyte immunoglobulin-like receptor B2, along with its ligands angiopoietin-like protein 2, and human leukocyte antigen-G in both transcriptomic data and immunohistochemical analysis. CSF3 upregulates these immune checkpoints in GC cells, with heterogeneous nuclear ribonucleoprotein H1 modulating this effect. These findings suggest that the CSF3/CSF3R pathway may play a role in promoting immunosuppression in GC. |
| Publish Date |
2025-01-18 08:11 |
| Citation |
Wang L, Wu Q, Zhang ZW, Zhang H, Jin H, Zhou XL, Liu JY, Li D, Liu Y, Fan ZS. Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric cancer. World J Gastrointest Oncol 2025; 17(2): 97858
|
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i2/97858.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i2.97858 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
