| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Long Wang, Qi Wu, Zong-Wen Zhang, Hui Zhang, Hui Jin, Xin-Liang Zhou, Jia-Yin Liu, Dan Li, Yan Liu and Zhi-Song Fan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of Hebei Province of China |
No. H2022206523 |
| Hebei Province Medical Science Research Project Plan |
No. 20230755 and No. 20240840 |
| Clinical Research Special Fund of Wu Jieping Medical Foundation, China |
No. 320.6750.2022-16-17 |
|
| Corresponding Author |
Zhi-Song Fan, Associate Chief Physician, Associate Professor, MD, PhD, Department of Oncology, The Fourth Hospital of Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang 050011, Hebei Province, China. fanzs@hebmu.edu.cn |
| Key Words |
Gastric cancer; Immunosuppressive receptor; Colony-stimulating factor 3; Colony-stimulating factor 3 receptor; Leukocyte immunoglobulin-like receptor B2; Angiopoietin-like protein 2; Human leukocyte antigen-G; Heterogeneous nuclear ribonucleoprotein H1 |
| Core Tip |
This study investigates the relationship between colony-stimulating factor 3 (CSF3)/colony-stimulating factor 3 receptor (CSF3R) and leukocyte immunoglobulin-like receptor B2, along with its ligands angiopoietin-like protein 2 and human leukocyte antigen-G, in gastric cancer (GC). High CSF3R expression correlates with increased levels of leukocyte immunoglobulin-like receptor B2, along with its ligands angiopoietin-like protein 2, and human leukocyte antigen-G in both transcriptomic data and immunohistochemical analysis. CSF3 upregulates these immune checkpoints in GC cells, with heterogeneous nuclear ribonucleoprotein H1 modulating this effect. These findings suggest that the CSF3/CSF3R pathway may play a role in promoting immunosuppression in GC. |
| Publish Date |
2025-01-18 08:11 |
| Citation |
<p>Wang L, Wu Q, Zhang ZW, Zhang H, Jin H, Zhou XL, Liu JY, Li D, Liu Y, Fan ZS. Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric cancer. <i>World J Gastrointest Oncol</i> 2025; 17(2): 97858</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i2/97858.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i2.97858 |
