Publication Name	World Journal of Diabetes
Manuscript ID	97910
Country	China

Received	2024-06-12 11:13
Peer-Review Started	2024-06-12 11:13
To Make the First Decision
Return for Revision	2024-08-15 04:55
Revised	2024-08-28 15:09
Second Decision	2024-10-14 08:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-13 09:00
Articles in Press	2024-11-13 09:00
Publication Fee Transferred	2024-11-20 05:13
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-28 07:58
Publish the Manuscript Online	2024-12-30 09:47

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Tacrolimus induces insulin receptor substrate 1 hyperphosphorylation and inhibits mTORc1/S6K1 cascade in HL7702 cells
Manuscript Source	Unsolicited Manuscript
All Author List	Hao-Yan Li, Yi Wang, Min Ran, Fei Gao, Bo-Yu Zhu, Hai-Ying Xiao and Chun Xu
ORCID	Author(s) ORCID Number Fei Gao http://orcid.org/0009-0009-9698-5652 Bo-Yu Zhu http://orcid.org/0009-0009-5712-2918 Hai-Ying Xiao http://orcid.org/0009-0004-5309-2727 Chun Xu http://orcid.org/0000-0002-4660-6185
Funding Agency and Grant Number
Corresponding Author	Chun Xu, Chief Physician, MD, PhD, Department of Endocrinology, The Third Medical Center of PLA General Hospital, No. 69 Yongding Road, Haidian District, Beijing 100039, China. xuchh2000-1@163.com
Key Words	Tacrolimus; Insulin resistance; Dyslipidemia; Ribosomal protein S6 kinase beta-1; Glucose metabolism
Core Tip	Tacrolimus, a calcineurin phosphatase inhibitor, prevents transplant rejection but induces insulin resistance and diabetes. This study explores its direct effects on insulin signaling in hepatocytes, revealing mechanisms involving calcineurin inhibition, dyslipidemia, and altered glucose metabolism.
Publish Date	2024-12-30 09:47
Citation	<p>Li HY, Wang Y, Ran M, Gao F, Zhu BY, Xiao HY, Xu C. Tacrolimus induces insulin receptor substrate 1 hyperphosphorylation and inhibits mTORc1/S6K1 cascade in HL7702 cells. <i>World J Diabetes</i> 2025; 16(2): 97910</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i2/97910.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i2.97910

Full Article (PDF)	WJD-16-97910-with-cover.pdf
Manuscript File	97910_Auto_Edited_062300.docx
Answering Reviewers	97910-answering-reviewers.pdf
Audio Core Tip	97910-audio.m4a
Biostatistics Review Certificate	97910-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	97910-conflict-of-interest-statement.pdf
Copyright License Agreement	97910-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	97910-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	97910-non-native-speakers.pdf
Peer-review Report	97910-peer-reviews.pdf
Journal Editor-in-Chief Review Report	97910-journal-editor-in-chief.pdf
Scientific Misconduct Check	97910-scientific-misconduct-check.png
Scientific Editor Work List	97910-scientific-editor-work-list.pdf
CrossCheck Report	97910-crosscheck-report.pdf