Publication Name	World Journal of Biological Chemistry
Manuscript ID	97938
Country	United States

Received	2024-06-13 03:43
Peer-Review Started	2024-06-13 03:43
To Make the First Decision
Return for Revision	2024-07-12 06:45
Revised	2024-07-21 16:08
Second Decision	2024-08-01 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-08-01 09:37
Articles in Press	2024-08-01 09:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-08-05 04:37
Publish the Manuscript Online	2024-08-08 08:24

ISSN	1949-8454 (online)
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Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Hmo1: A versatile member of the high mobility group box family of chromosomal architecture proteins
Manuscript Source	Invited Manuscript
All Author List	Xin Bi
ORCID	Author(s) ORCID Number Xin Bi http://orcid.org/0000-0001-6962-6229
Funding Agency and Grant Number
Corresponding Author	Xin Bi, PhD, Professor, Department of Biology, University of Rochester, 500 Joseph C, Wilson Boulevard, Rochester, NY 14627, United States. xin.bi@rochester.edu
Key Words	Hmo1; High mobility group box proteins; Chromatin; Chromatin remodeling; Gene regulation; Ribosomal DNA; Ribosomal protein genes; DNA damage response; Linker histone
Core Tip	The evolutionarily conserved high mobility group box (HMGB) family proteins are major non-histone chromosomal architectural factors characterized by one or more HMGB motifs that bind DNA in a sequence nonspecific fashion. They play a major role in chromatin dynamics that impact various cellular functions. The Saccharomyces cerevisiae (yeast hereafter) HMGB protein Hmo1 contains two HMGB motifs. Hmo1 functions in multiple cellular processes including genome maintenance, chromatin dynamics, gene transcription, and DNA damage response. However, the underlying mechanisms have only been partially elucidated. Moreover, to what extent Hmo1 functionally resembles its mammalian counterparts has not been fully addressed. Recent studies revealed that Hmo1 binds and destabilizes/disrupts nucleosome similarly as well-characterized human HMGB proteins and that Hmo1 plays a role in maintaining a topological architecture of genes in the yeast genome.
Publish Date	2024-08-08 08:24
Citation	<p>Bi X. Hmo1: A versatile member of the high mobility group box family of chromosomal architecture proteins. <i>World J Biol Chem</i> 2024; 15(1): 97938</p>
URL	https://www.wjgnet.com/1949-8454/full/v15/i1/97938.htm
DOI	https://dx.doi.org/10.4331/wjbc.v15.i1.97938

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