| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Observational Study |
| Article Title |
MiRNA-200a and miRNA-200b expression, and vitamin-D level: Prognostic significance in obese non-diabetic and obese type 2 diabetes mellitus individuals
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Abrar Fahad Alshahrani, Fauzia Ashfaq, Abdulrahman A. Alsayegh, Mohammed Bajahzer, Mohammad Idreesh Khan and Mirza Masroor Ali Beg |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia |
ISP-24 |
|
| Corresponding Author |
Mirza Masroor Ali Beg, PhD, Associate Professor, Faculty of Medicine, Alatoo International University, 1/8 Ankara Street, Bishkek, Kyrgyzstan, Bishkek 720048, Kyrgyzstan. mirzamasroor1986@gmail.com |
| Key Words |
Obesity; Type 2 diabetes mellitus; MiRNA200a; MiRNA200b; Vitamin-D; Prognosis |
| Core Tip |
Obesity and being overweight are widespread health issues in modern societies, and their growing prevalence poses a serious public health challenge due to both the financial burden and health risks involved. In humans, the expression of miRNAs in adipose tissue has been demonstrated to be associated with various metabolic factors, including body mass index, adipogenesis, blood sugar levels, and leptin concentrations. The miR-200 family is reported to be more prevalent in human β-cells than in α-cells. The expression of miR-200a and miR-200b is regulated by Txnip (thioredoxin-interacting protein), a proapoptotic regulator. It has been suggested that a deficiency in vitamin D is closely associated with obesity and plays a role in the development of insulin resistance and type 2 diabetes mellitus (T2DM). Studies have indicated that vitamin D influences the expression of miRNAs both in adipocytes in laboratory settings and in adipose tissue in living organisms. Therefore, current research work explored the miRNA-200a, miRNA-200b expression, and vitamin-D level among obese non-diabetic and obese T2DM. |
| Publish Date |
2024-10-31 07:21 |
| Citation |
<p>Alshahrani AF, Ashfaq F, Alsayegh AA, Bajahzer M, Khan MI, Beg MMA. MiRNA-200a and miRNA-200b expression, and vitamin-D level: Prognostic significance in obese non-diabetic and obese type 2 diabetes mellitus individuals. <i>World J Clin Cases</i> 2024; 12(36): 6916-6925</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v12/i36/6916.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v12.i36.6916 |
