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Articles Published Processes
12/2/2014 10:47:00 AM | Browse: 1303 | Download: 1507
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Received |
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2014-03-01 11:09 |
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Peer-Review Started |
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2014-03-01 18:19 |
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First Decision by Editorial Office Director |
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2014-05-02 14:19 |
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Revised |
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2014-05-23 21:50 |
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Second Decision by Editor |
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2014-07-22 16:50 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-07-22 17:10 |
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Articles in Press |
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2014-07-22 18:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-11-14 19:57 |
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Publish the Manuscript Online |
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2014-12-02 10:46 |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Topic Highlights |
| Article Title |
Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Natasha Irrera, Alessandra Bitto, Monica Interdonato, Francesco Squadrito and Domenica Altavilla |
| Funding Agency and Grant Number |
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| Corresponding Author |
Francesco Squadrito, MD, Professor, Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Messina, Torre Biologica 5th floor, c/o AOU Policlinico G. Martino, Via C. Valeria Gazzi, 98125 Messina, Italy. francesco.squadrito@unime.it |
| Key Words |
Experimental acute pancreatitis; Mitogen-activated protein kinases; Mitogen-activated protein kinases inhibitors; Cytokines; Cholecystokinin; Cerulein |
| Core Tip |
The review focuses on the role of mitogen-activated protein kinases (MAPKs) in the treatment of acute pancreatitis. In fact, acute pancreatitis is a disease characterized by a marked inflammatory reaction and it is usually associated with severe upper abdominal pain, organ failure and also mortality. The activation of MAPKs is an early event in AP and exerts a central role in the onset and development of acute pancreatitis. Thanks to the pivotal function played by MAPKs in acute pancreatitis, the use of specific inhibitors may represent a potential therapeutic target for the treatment of this inflammatory disease. |
| Publish Date |
2014-12-02 10:46 |
| Citation |
Irrera N, Bitto A, Interdonato M, Squadrito F, Altavilla D. Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis. World J Gastroenterol 2014; 20(44): 16535-16543 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i44/16535.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i44.16535 |
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