Publication Name	World Journal of Gastroenterology
Manuscript ID	9797
Country	Italy

Received	2014-03-01 11:09
Peer-Review Started	2014-03-01 18:19
To Make the First Decision	2014-04-28 14:10
Return for Revision	2014-05-02 14:19
Revised	2014-05-23 21:50
Second Decision	2014-07-22 16:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-22 17:10
Articles in Press	2014-07-22 18:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-14 19:57
Publish the Manuscript Online	2014-12-02 10:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Topic Highlights
Article Title	Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Natasha Irrera, Alessandra Bitto, Monica Interdonato, Francesco Squadrito and Domenica Altavilla
Funding Agency and Grant Number
Corresponding Author	Francesco Squadrito, MD, Professor, Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Messina, Torre Biologica 5th floor, c/o AOU Policlinico G. Martino, Via C. Valeria Gazzi, 98125 Messina, Italy. francesco.squadrito@unime.it
Key Words	Experimental acute pancreatitis; Mitogen-activated protein kinases; Mitogen-activated protein kinases inhibitors; Cytokines; Cholecystokinin; Cerulein
Core Tip	The review focuses on the role of mitogen-activated protein kinases (MAPKs) in the treatment of acute pancreatitis. In fact, acute pancreatitis is a disease characterized by a marked inflammatory reaction and it is usually associated with severe upper abdominal pain, organ failure and also mortality. The activation of MAPKs is an early event in AP and exerts a central role in the onset and development of acute pancreatitis. Thanks to the pivotal function played by MAPKs in acute pancreatitis, the use of specific inhibitors may represent a potential therapeutic target for the treatment of this inflammatory disease.
Publish Date	2014-12-02 10:46
Citation	Irrera N, Bitto A, Interdonato M, Squadrito F, Altavilla D. Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis. World J Gastroenterol 2014; 20(44): 16535-16543
URL	http://www.wjgnet.com/1007-9327/full/v20/i44/16535.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i44.16535

Full Article (PDF)	WJG-20-16535.pdf
Full Article (Word)	WJG-20-16535.doc
Manuscript File	9797-Review.doc
Answering Reviewers	9797-Answering reviewers.pdf
Copyright License Agreement	9797-Copyright assignment.pdf
Peer-review Report	9797-Peer reivew(s).pdf
Scientific Misconduct Check	9797-CrossCheck.jpg
Scientific Editor Work List	9797-Scientific editor work list.pdf