| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Oxidative stress-induced circSOD2 inhibits osteogenesis through sponging miR-29b in metabolic-associated fatty liver disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Liang-Ping Li, Xiao-Ying Chen, Hong-Bo Liu, Yi Zhu, Min-Jie Xie, Yong-Jian Li, Meng Luo, Mugahed Albahde, Hong-Yu Zhang and Jian-Ying Lou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National and Zhejiang Provincial Administration of Traditional Chinese Medicine co-construction project |
GZY-ZJ-KJ-24080 |
| Medical Science and Technology Project of Zhejiang Province |
2024XY228 |
|
| Corresponding Author |
Jian-Ying Lou, Professor, Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. Jiefang Road, Shangcheng District, Hangzhou 310009, Zhejiang Province, China. loujianying@zju.edu.cn |
| Key Words |
Circular RNAs; MicroRNAs; Oxidative stress; Osteogenesis; Non-alcoholic fatty liver disease; Osteoporosis |
| Core Tip |
Emerging evidence indicates that metabolic-associated fatty liver disease (MAFLD) closely associated with oxidative stress, is linked to bone metabolic diseases. Altered expression profiles of liver circular RNAs (circRNAs) have been observed in MAFLD. This study explores the upstream and downstream mechanisms of circSOD2 upregulation in osteogenesis by identifying differentially expressed circRNAs in MAFLD livers. Results demonstrated that circSOD2 upregulation in hepatocytes induced by oxidative stress inhibits osteogenic differentiation of bone marrow mesenchymal stem cells by sponging miR-29b. These findings provide a better understanding of the relationship between MAFLD and osteoporosis from the perspective of circRNAs. |
| Publish Date |
2025-02-18 09:00 |
| Citation |
<p>Li LP, Chen XY, Liu HB, Zhu Y, Xie MJ, Li YJ, Luo M, Albahde M, Zhang HY, Lou JY. Oxidative stress-induced circSOD2 inhibits osteogenesis through sponging miR-29b in metabolic-associated fatty liver disease. <i>World J Gastroenterol</i> 2025; 31(9): 98027</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i9/98027.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i9.98027 |
