Publication Name	World Journal of Gastroenterology
Manuscript ID	9804
Country	China

Received	2014-03-01 12:16
Peer-Review Started	2014-03-01 18:52
To Make the First Decision	2014-05-13 20:29
Return for Revision	2014-05-21 08:51
Revised	2014-06-09 00:00
Second Decision	2014-07-11 17:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-07-11 17:17
Articles in Press	2014-07-11 17:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-19 20:21
Typeset the Manuscript	2014-11-11 10:24
Publish the Manuscript Online	2014-11-20 20:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Topic Highlights
Article Title	Calcium signalling of pancreatic acinar cells in the pathogenesis of pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Jun Li, Rui Zhou, Jian Zhang and Zong-Fang Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30171167 National Natural Science Foundation of China 30901945 Specialized Research Fund for the Doctoral Program of Higher Education 20130201130009
Corresponding Author	Zong-Fang Li, MD, PhD, National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, Department of General Surgery, the Second Affiliated Hospital of Xi’an Jiaotong University College of Medicine, No. 157 West 5th Road, Xi'an 710004, Shaanxi Province, China. lzf2568@gmail.com
Key Words	Pancreatitis; Calcium signaling; Pancreatic acinar cells; Overload; Cell injury
Core Tip	Ca2+ overload is crucial in the pathogenesis of pancreatitis which results in trypsin activation, vacuolization and necrosis. Such cell injury results from increased Ca2+ released from intracellular endoplasmic reticulum Ca2+ stores , increased Ca2+ entry through the plasma membrane and Ca2+ pump defects. Current findings have provided further insight into the roles and mechanisms of Ca2+ overload in pancreatitis. The absence of specific treatments is a spur to research. This review summarize recent advances in our understanding of Ca2+ signalling in the pathogenesis of pancreatitis, and discuss how research has guided our search for potential therapeutic targets.
Publish Date	2014-11-20 20:51
Citation	Li J, Zhou R, Zhang J, Li ZF. Calcium signaling of pancreatic acinar cells in the pathogenesis of pancreatitis. World J Gastroenterol 2014; 20(43): 16146-16152
URL	http://www.wjgnet.com/1007-9327/full/v20/i43/16146.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i43.16146

Full Article (PDF)	WJG-20-16146.pdf
Full Article (Word)	WJG-20-16146.doc
Manuscript File	9804-Review.doc
Answering Reviewers	9804-Answering Reviewers.pdf
Copyright License Agreement	9804-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20140228114204.pdf
Peer-review Report	9804-Peer reviews.pdf
Scientific Misconduct Check	9804-CrossCheck.jpg
Scientific Editor Work List	9804-Scientific editor work list.pdf