Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	98040
Country	China

Received	2024-08-21 03:40
Peer-Review Started	2024-06-16 13:52
To Make the First Decision
Return for Revision	2024-09-04 04:42
Revised	2024-09-17 18:40
Second Decision	2024-10-16 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-16 07:41
Articles in Press	2024-10-16 07:41
Publication Fee Transferred	2024-10-17 05:12
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-31 03:04
Publish the Manuscript Online	2024-11-12 12:23

ISSN	1948-5204 (online)
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression
Manuscript Source	Unsolicited Manuscript
All Author List	Yuan-Chen Zhou, Qian-Qian Wang, Ge-Yu-Jia Zhou, Teng-Fei Yin, Dong-Yan Zhao, Xi-Zhen Sun, Chang Tan, Lei Zhou and Shu-Kun Yao
ORCID	Author(s) ORCID Number Yuan-Chen Zhou http://orcid.org/0000-0001-6024-6246 Qian-Qian Wang http://orcid.org/0000-0002-7709-2121 Ge-Yu-Jia Zhou http://orcid.org/0000-0002-4196-1436 Teng-Fei Yin http://orcid.org/0000-0003-1140-8637 Dong-Yan Zhao http://orcid.org/0000-0002-7026-068X Xi-Zhen Sun http://orcid.org/0000-0001-9967-5726 Chang Tan http://orcid.org/0000-0002-0969-1851 Shu-Kun Yao http://orcid.org/0000-0002-8512-2589
Funding Agency and Grant Number	Funding Agency Grant Number National Key Development Plan for Precision Medicine Research 2017YFC0910002
Corresponding Author	Shu-Kun Yao, MD, PhD, Chief Physician, Doctor, Doctor, Professor, Graduate School, Peking University China-Japan Friendship School of Clinical Medicine, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Key Words	Colorectal cancer; Proteomics; Shank-associated RH domain interactor; Matrine; Apoptosis
Core Tip	Despite advances in therapy for colorectal cancer (CRC), the 5-year survival rate for CRC patients in China remains only 56.9%. This study explored the effects of matrine on CRC by targeting a newly identified anti-apoptotic protein, Shank-associated RH domain interactor (SHARPIN). SHARPIN was discovered through proteomic analysis and its expression was validated in both the TCGA database and our patient cohort using immunohistochemistry. Inhibiting SHARPIN expression led to increased apoptosis and reduced proliferation, invasion, and migration of CRC cells in vitro. Matrine's ability to inhibit SHARPIN and induce apoptosis highlights its potential as a promising therapeutic agent for CRC.
Publish Date	2024-11-12 12:23
Citation	<p>Zhou YC, Wang QQ, Zhou GYJ, Yin TF, Zhao DY, Sun XZ, Tan C, Zhou L, Yao SK. Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression. <i>World J Gastrointest Oncol</i> 2024; 16(12): 4700-4715</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i12/4700.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i12.4700

Full Article (PDF)	WJGO-16-4700-with-cover.pdf
Manuscript File	98040_Auto_Edited_005532.docx
Answering Reviewers	98040-answering-reviewers.pdf
Audio Core Tip	98040-audio.mp3
Biostatistics Review Certificate	98040-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98040-conflict-of-interest-statement.pdf
Copyright License Agreement	98040-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98040-foundation-statement.pdf
Institutional Review Board Approval Form or Document	98040-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	98040-non-native-speakers.pdf
Supplementary Material	98040-supplementary-material.pdf
Peer-review Report	98040-peer-reviews.pdf
Scientific Misconduct Check	98040-scientific-misconduct-check.png
Scientific Editor Work List	98040-scientific-editor-work-list.pdf
CrossCheck Report	98040-crosscheck-report.png
CrossCheck Report	98040-crosscheck-report.pdf