Publication Name	World Journal of Radiology
Manuscript ID	98045
Country	China

Received	2024-06-17 09:13
Peer-Review Started	2024-06-17 09:13
To Make the First Decision
Return for Revision	2024-08-29 09:26
Revised	2024-09-06 02:19
Second Decision	2024-09-12 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-12 07:34
Articles in Press	2024-09-12 07:34
Publication Fee Transferred	2024-09-12 12:43
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-14 02:03
Publish the Manuscript Online	2024-11-27 09:26

ISSN	1949-8470 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Clinical Neurology
Manuscript Type	Prospective Study
Article Title	Right-to-left shunt detection via synchronized contrast transcranial Doppler combined with contrast transthoracic echocardiography: A preliminary study
Manuscript Source	Unsolicited Manuscript
All Author List	Man-Juan Yao, Ying-Ying Zhao, Shui-Ping Deng, Hua-Hua Xiong, Jing Wang, Li-jie Ren and Li-Ming Cao
ORCID	Author(s) ORCID Number Man-Juan Yao http://orcid.org/0009-0008-8537-3709 Li-Ming Cao http://orcid.org/0000-0003-2836-9347
Funding Agency and Grant Number	Funding Agency Grant Number The Shenzhen Second People’s Hospital Clinical Research Fund of the Shenzhen High-level Hospital Construction Project 20223357021 and 20243357001 Research Project of Teaching Reform in Shenzhen Second People’s Hospital No. 202209 Guangdong Province Basic and Applied Basic Research Fund Project 2020B1515120061
Corresponding Author	Li-Ming Cao, MD, PhD, Adjunct Associate Professor, Department of Neurology, The First Affiliated Hospital of Shenzhen University, No. 3002 Sungang West Road, Shenzhen 518000, Guangdong Province, China. caolm-2007@163.com
Key Words	Contrast transcranial Doppler; Contrast transthoracic echocardiography; Cryptogenic stroke; Multimodal ultrasonography; Patent foramen ovale; Right-to-left shunt
Core Tip	Synchronized multimodal ultrasonography, combining contrast transcranial Doppler (cTCD) with contrast transthoracic echocardiography (cTTE), enhances the accuracy of right-to-left shunt (RLS) detection in patients with cryptogenic stroke, migraine, and dizziness. Traditional methods relying solely on cTCD or cTTE may result in false-negative or underestimated RLS results. Synchronized testing offers a more comprehensive assessment, enabling the identification of inherently large RLS and supporting precise etiological analyses. Incorporating synchronized multimodal ultrasonography into clinical practice can enhance patient outcomes by facilitating more accurate diagnosis and informed treatment decision-making in individuals with cryptogenic stroke, migraine, and dizziness.
Publish Date	2024-11-27 09:26
Citation	<p>Yao MJ, Zhao YY, Deng SP, Xiong HH, Wang J, Ren LJ, Cao LM. Right-to-left shunt detection via synchronized contrast transcranial Doppler combined with contrast transthoracic echocardiography: A preliminary study. <i>World J Radiol</i> 2024; 16(11): 657-667</p>
URL	https://www.wjgnet.com/1949-8470/full/v16/i11/657.htm
DOI	https://dx.doi.org/10.4329/wjr.v16.i11.657

Full Article (PDF)	WJR-16-657-with-cover.pdf
CONSORT 2010 Statement	98045-CONSORT-2010-statement.pdf
Manuscript File	98045_Auto_Edited_023517.docx
Answering Reviewers	98045-answering-reviewers.pdf
Audio Core Tip	98045-audio.m4a
Biostatistics Review Certificate	98045-biostatistics-statement.pdf
Clinical Trial Registration Statement	98045-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form	98045-conflict-of-interest-statement.pdf
Copyright License Agreement	98045-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98045-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	98045-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	98045-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	98045-non-native-speakers.pdf
Peer-review Report	98045-peer-reviews.pdf
Scientific Misconduct Check	98045-scientific-misconduct-check.png
Scientific Editor Work List	98045-scientific-editor-work-list.pdf
CrossCheck Report	98045-crosscheck-report.pdf