| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Macrophage-derived cathepsin L promotes epithelial-mesenchymal transition and M2 polarization in gastric cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lu-Xi Xiao, Xun-Jun Li, Hai-Yi Yu, Ren-Jie Qiu, Zhong-Ya Zhai, Wen-Fu Ding, Man-Sheng Zhu, Wu Zhong, Chuan-Fa Fang, Jia Yang, Tao Chen and Jiang Yu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The National Natural Science Foundation of China |
No. 82272087 |
| The National Natural Science Foundation of China |
No. 82103150 |
| The Guangdong Natural Science Foundation Outstanding Youth Project, China |
No. 2021B1515020055 |
| The Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Cancer, China |
No. 2020B121201004 |
|
| Corresponding Author |
Jiang Yu, MD, Adjunct Professor, Doctor, Doctor, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, No. 1023 Shatai South Road, Baiyun District, Guangzhou 510515, Guangdong Province, China. balbc@163.com |
| Key Words |
Gastric cancer; Invasion and metastasis; Epithelial-mesenchymal transition; Inflammation; Immunology; Tumor-associated macrophages; Cancer prevention |
| Core Tip |
Advanced gastric tumors are extremely prone to metastasize into the peritoneum and herald a dismal prognosis with limited therapeutic options. Certain intraperitoneal chemotherapies have been examined, but their response is still underperforming. Discovering target molecules associated with the development of gastric cancer peritoneal metastasis (GCPM) is critical for improving clinical therapy. In our study, we revealed that tumor-associated macrophage-derived cathepsin L can significantly facilitate gastric cancer invasion and metastasis both in vitro and in vivo. Immune-related therapy may be a promising approach to improve the prognosis of patients with GCPM. |
| Publish Date |
2024-11-26 07:20 |
| Citation |
<p>Xiao LX, Li XJ, Yu HY, Qiu RJ, Zhai ZY, Ding WF, Zhu MS, Zhong W, Fang CF, Yang J, Chen T, Yu J. Macrophage-derived cathepsin L promotes epithelial-mesenchymal transition and M2 polarization in gastric cancer. <i>World J Gastroenterol</i> 2024; 30(47): 5032-5054</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i47/5032.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i47.5032 |
