Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	98070
Country	China

Received	2024-06-17 08:00
Peer-Review Started	2024-06-17 08:00
To Make the First Decision
Return for Revision	2024-07-09 02:53
Revised	2024-09-03 03:43
Second Decision	2024-10-18 01:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-18 09:20
Articles in Press	2024-10-18 09:20
Publication Fee Transferred	2024-10-24 01:18
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-29 14:42
Publish the Manuscript Online	2024-11-12 12:23

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Enhancing the radiosensitivity of colorectal cancer cells by reducing spermine synthase through promoting autophagy and DNA damage
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Bin Guo, Yue-Ming Wu and Zhi-Zhao Lin
ORCID	Author(s) ORCID Number Yu-Bin Guo http://orcid.org/0000-0002-7748-1805
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82102996 Guangdong Provincial Natural Science Foundation 2022A1515010517 Guangzhou Science and Technology Plan Project 202201011016 President Foundation of Nanfang Hospital, Southern Medical University 2020C038
Corresponding Author	Yu-Bin Guo, PhD, Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou 510515, Guangdong Province, China. 928526639@qq.com
Key Words	Spermine synthase; Colorectal cancer; Radiosensitivity; Autophagy; DNA damage
Core Tip	This study highlighted spermine synthase (SMS) as a pivotal molecule regulating DNA damage and autophagy in cancer cells. SMS promoted DNA repair and activated the mammalian target of rapamycin signaling pathway, resulting in the inhibition of cellular autophagy. Collectively, SMS emerges as a promising therapeutic target to enhance colorectal cancer radiosensitivity, providing novel insights into the development of colorectal cancer treatment strategies.
Publish Date	2024-11-12 12:23
Citation	<p>Guo YB, Wu YM, Lin ZZ. Enhancing the radiosensitivity of colorectal cancer cells by reducing spermine synthase through promoting autophagy and DNA damage. <i>World J Gastrointest Oncol</i> 2024; 16(12): 4716-4727</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i12/4716.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i12.4716

Full Article (PDF)	WJGO-16-4716-with-cover.pdf
Manuscript File	98070_Auto_Edited_025654.docx
Answering Reviewers	98070-answering-reviewers.pdf
Audio Core Tip	98070-audio.mp3
Biostatistics Review Certificate	98070-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98070-conflict-of-interest-statement.pdf
Copyright License Agreement	98070-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98070-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	98070-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	98070-non-native-speakers.pdf
Peer-review Report	98070-peer-reviews.pdf
Scientific Misconduct Check	98070-scientific-misconduct-check.png
Scientific Editor Work List	98070-scientific-editor-work-list.pdf
CrossCheck Report	98070-crosscheck-report.png
CrossCheck Report	98070-crosscheck-report.pdf