BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/21/2024 11:22:32 PM | Browse: 90 | Download: 660
 |
Received |
|
2024-06-18 02:23 |
|
Peer-Review Started |
|
2024-06-18 02:23 |
|
First Decision by Editorial Office Director |
|
2024-07-03 05:49 |
|
Return for Revision |
|
2024-07-03 05:49 |
|
Revised |
|
2024-07-09 09:37 |
|
Publication Fee Transferred |
|
2024-07-26 01:00 |
|
Second Decision by Editor |
|
2024-07-25 02:34 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2024-07-25 06:23 |
|
Articles in Press |
|
2024-07-25 06:23 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2024-08-06 03:45 |
|
Publish the Manuscript Online |
|
2024-08-21 23:22 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Dynamics of glutamine synthetase expression in hepatic ischemia-reperfusion injury: Implications for therapeutic interventions
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Hao Huang, Meng-Qi Dong, Feng-Yong Liu and Wei-Jie Zhou |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Wei-Jie Zhou, PhD, Professor, State Key Laboratory of Organ Failure Research, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Road, Guangzhou 510515, Guangdong Province, China. weijiezhouum@163.com |
| Key Words |
Hepatic ischemia-reperfusion; Glutamine synthetase; Central vein; Liver; Injury repair |
| Core Tip |
The role of glutamine synthetase (GS) in hepatic ischemia‒reperfusion injury (IRI), a major challenge in liver surgery and transplantation, was explored in this study. Using a mouse model, dynamic GS expression patterns were observed. The expression of GS, which is typically high around the central vein in normal livers, significantly decreases postreperfusion, which is correlated with liver damage. The re-expression of GS during liver recovery highlights its critical role in cellular defense. These findings suggest that modulating GS expression could be a therapeutic strategy to reduce IRI, improving patient outcomes after liver transplantation. |
| Publish Date |
2024-08-21 23:22 |
| Citation |
Huang ZH, Dong MQ, Liu FY, Zhou WJ. Dynamics of glutamine synthetase expression in hepatic ischemia-reperfusion injury: Implications for therapeutic interventions. World J Hepatol 2024; 16(8): 1177-1184 |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i8/1177.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i8.1177 |
© 2004-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
