| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Unraveling the role of cancer-associated fibroblasts in colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Yu Cui, Jing Ma, Xin-Xin Gao, Zhi-Mei Sheng, Zi-Xin Pan, Li-Hong Shi and Bao-Gang Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Bao-Gang Zhang, MD, PhD, Doctor, Doctor, Teacher, Department of Pathology, Affiliated Hospital of Weifang Medical University, No. 4948 East Shengli Street, Quewen District, Weifang 261000, Shandong Province, China. zbg0903@hotmail.com |
| Key Words |
Colorectal cancer; Cancer-associated fibroblasts; Therapeutic strategies; Microbiota; Neovascularization |
| Core Tip |
Within the intricate milieu of colorectal cancer (CRC) tissues, cancer-associated fibroblasts (CAFs) act as pivotal orchestrators, wielding considerable influence over tumor progression. This review endeavors to dissect the multifaceted functions of CAFs within the realm of CRC, thereby highlighting their indispensability in fostering CRC malignant microenvironment and thus indicating the development of CAFs-targeted therapeutic interventions. Through a comprehensive synthesis of current knowledge, this review endeavors to delineate insights into CAFs-mediated modulation of cancer cell proliferation, invasiveness, immune evasion, neovascularization, elucidating the intricate web of interactions that sustain the pro-tumor metabolism and secretion of multiple factors. Additionally, recognizing the high level of heterogeneity within CAFs is crucial, as they encompass a range of subtypes, including myofibroblastic CAFs, inflammatory CAFs, antigen-presenting CAFs, and vessel-associated CAFs. Innovatively, the symbiotic relationship between CAFs and the intestinal microbiota is explored, shedding light on a novel dimension of CRC pathogenesis. Despite remarkable progress, the orchestrated dynamic functions of CAFs remains incompletely deciphered, underscoring the need for continued research endeavors for therapeutic advancements in CRC management. |
| Publish Date |
2024-11-12 12:23 |
| Citation |
<p>Cui JY, Ma J, Gao XX, Sheng ZM, Pan ZX, Shi LH, Zhang BG. Unraveling the role of cancer-associated fibroblasts in colorectal cancer. <i>World J Gastrointest Oncol</i> 2024; 16(12): 4565-4578</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i12/4565.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i12.4565 |
