Publication Name	World Journal of Gastroenterology
Manuscript ID	98174
Country	China

Received	2024-06-19 13:44
Peer-Review Started	2024-06-19 13:44
To Make the First Decision
Return for Revision	2024-09-30 06:07
Revised	2024-10-29 15:02
Second Decision	2024-12-23 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-23 06:40
Articles in Press	2024-12-23 06:40
Publication Fee Transferred	2025-02-17 12:25
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-04 10:07
Publish the Manuscript Online	2025-03-26 08:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Involvement of the NLRP3/IL-1β pathway in activation and effector functions of γδT17 cells in patients with ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Jing Ma, Feng-Yun Wang and Xu-Dong Tang
ORCID	Author(s) ORCID Number Feng-Yun Wang http://orcid.org/0000-0002-4058-7905 Xu-Dong Tang http://orcid.org/0000-0002-7144-9273
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82341233 China Academy of Chinese Medical Sciences Excellent Young Talent Cultivation Fund ZZ17-YQ-007
Corresponding Author	Xu-Dong Tang, PhD, Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No.16 Inner South Street, Dongzhimen, Dongcheng District, Beijing 100091, China. tougaozhuanyong6@126.com
Key Words	Ulcerative colitis; Abnormal immune response; γδT17 cells; NLR family pyrin domain containing 3/interleukin-1β pathway; Observational study
Core Tip	The contribution of γδT17 cells in patients with ulcerative colitis (UC) is controversial. In this study, serum samples from healthy volunteers and UC patients were analysed for associated inflammatory factors, and five randomly selected colonic mucosal tissue biopsy samples from each group were analysed by immunohistochemistry and immunofluorescence to clarify the role of γδT17 cells in UC patients. The serum levels of inflammatory factors secreted after γδT17 cell activation were significantly elevated in patients with UC, the expression level of γδT17 cells in colonic mucosal tissues was significantly elevated, and the NLR family pyrin domain containing 3/interleukin-1β signaling pathway was hyperactivated.
Publish Date	2025-03-26 08:40
Citation	<p>Ma J, Wang FY, Tang XD. Involvement of the NLRP3/IL-1β pathway in activation and effector functions of γδT17 cells in patients with ulcerative colitis. <i>World J Gastroenterol</i> 2025; 31(12): 98174</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i12/98174.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i12.98174

Full Article (PDF)	WJG-31-98174-with-cover.pdf
STROBE Statement	98174-STROBE-statement.pdf
Manuscript File	98174_Auto_Edited_023621.docx
Answering Reviewers	98174-answering-reviewers.pdf
Audio Core Tip	98174-audio.m4a
Biostatistics Review Certificate	98174-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98174-conflict-of-interest-statement.pdf
Copyright License Agreement	98174-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98174-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	98174-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	98174-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	98174-non-native-speakers.pdf
Video	98174-video.mp4
Peer-review Report	98174-peer-reviews.pdf
Scientific Misconduct Check	98174-scientific-misconduct-check.png
Scientific Editor Work List	98174-scientific-editor-work-list.pdf
CrossCheck Report	98174-crosscheck-report.pdf