Publication Name	World Journal of Hepatology
Manuscript ID	98182
Country	United Kingdom

Received	2024-06-19 15:53
Peer-Review Started	2024-06-19 15:53
To Make the First Decision
Return for Revision	2024-08-04 16:53
Revised	2024-09-09 08:34
Second Decision	2024-09-24 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-25 11:27
Articles in Press	2024-09-25 11:27
Publication Fee Transferred	2024-09-28 19:56
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-17 01:26
Publish the Manuscript Online	2024-11-06 09:51

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Sensitivity of diagnosis of spontaneous bacterial peritonitis is higher with the automated cell count method
Manuscript Source	Unsolicited Manuscript
All Author List	Juan G Acevedo-Haro, Waddah Mohamed, Prebashan Moodley, Oliver Bendall, Kris Bennett, Nigel Keelty, Sally Chan, Sam Waddy, Joanne Hosking, Wayne Thomas and Robert Tilley
ORCID	Author(s) ORCID Number Juan G Acevedo-Haro http://orcid.org/0000-0003-4507-2422
Funding Agency and Grant Number
Corresponding Author	Juan G Acevedo-Haro, PhD, Doctor, Doctor, South West Liver Unit, University Hospitals Plymouth NHS Trust, Derriford Road, Plymouth PL6 8DH, United Kingdom. jacevedo@nhs.net
Key Words	Spontaneous bacterial peritonitis; Diagnosis; Cirrhosis; Bacterial infection; Automated cell count method; Manual cell count method; Ascitic fluid
Core Tip	The traditional cutoff recommended by international guidelines (250 polymorphs × 106/L in ascitic fluid) to diagnose spontaneous bacterial peritonitis (SBP) was set when automated cell counters were not available. There are no data comparing the manual and the automated cell count in patients with cirrhosis against gold standard SBP cases and employing the cell analyzers currently available. This study compares both cells count methods against SBP cases fulfilling gold standard criteria and shows that the automated method has better sensitivity: 80% vs 52%, P = 0.02 and has a good specificity (96%). It also shows that the most accurate cutoff to diagnose SBP is 0.2 polymorphs × 109/L. Guidelines should recommend the use of one of the modern automated cell counters instead of the manual method.
Publish Date	2024-11-06 09:51
Citation	<p>Acevedo-Haro JG, Mohamed W, Moodley P, Bendall O, Bennett K, Keelty N, Chan S, Waddy S, Hosking J, Thomas W, Tilley R. Sensitivity of diagnosis of spontaneous bacterial peritonitis is higher with the automated cell count method. <i>World J Hepatol</i> 2024; 16(11): 1265-1281</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i11/1265.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i11.1265

Full Article (PDF)	WJH-16-1265-with-cover.pdf
STROBE Statement	98182-STROBE-statement.pdf
Manuscript File	98182_Auto_Edited_091435.docx
Answering Reviewers	98182-answering-reviewers.pdf
Audio Core Tip	98182-audio.aac
Biostatistics Review Certificate	98182-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98182-conflict-of-interest-statement.pdf
Copyright License Agreement	98182-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	98182-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	98182-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	98182-non-native-speakers.pdf
Peer-review Report	98182-peer-reviews.pdf
Scientific Misconduct Check	98182-scientific-misconduct-check.png
Scientific Editor Work List	98182-scientific-editor-work-list.pdf
CrossCheck Report	98182-crosscheck-report.pdf