Publication Name	World Journal of Gastroenterology
Manuscript ID	98208
Country	China

Received	2024-06-20 11:00
Peer-Review Started	2024-06-20 11:00
To Make the First Decision
Return for Revision	2024-09-16 04:53
Revised	2024-09-26 07:36
Second Decision	2024-11-08 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-08 06:42
Articles in Press	2024-11-08 06:42
Publication Fee Transferred	2024-11-11 13:50
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-18 02:19
Publish the Manuscript Online	2024-11-29 08:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	N6-methyladenosine-modified long non-coding RNA KIF9-AS1 promotes stemness and sorafenib resistance in hepatocellular carcinoma by upregulating SHOX2 expression
Manuscript Source	Unsolicited Manuscript
All Author List	Yong Yu, Xiang-Hong Lu, Jin-Song Mu, Jiang-Yun Meng, Jiang-Shan Sun, Hai-Xu Chen, Yang Yan and Ke Meng
ORCID	Author(s) ORCID Number Yong Yu http://orcid.org/0009-0006-9526-2012 Xiang-Hong Lu http://orcid.org/0009-0007-4304-8660 Jin-Song Mu http://orcid.org/0000-0002-4016-7513 Jiang-Yun Meng http://orcid.org/0000-0002-6531-1673 Hai-Xu Chen http://orcid.org/0000-0003-4359-960X Yang Yan http://orcid.org/0000-0001-8019-7314 Ke Meng http://orcid.org/0000-0002-2460-4728
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82271628
Corresponding Author	Ke Meng, MD, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese People’s Liberation Army General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. mengke301@126.com
Key Words	Hepatocellular carcinoma; Stemness; Sorafenib resistance; Long non-coding RNA KIF9-AS1; Short stature homeobox 2
Core Tip	Hepatocellular carcinoma (HCC) is a highly aggressive tumor with a poor prognosis. Our previous investigation revealed that knockdown of the long non-coding RNA KIF9-AS1 suppressed HCC progression. However, the role of KIF9-AS1 in cancer stemness and drug resistance in HCC remains unclear. This study revealed that N6-methyladenosine modification of KIF9-AS1 promotes stemness and sorafenib resistance in HCC by upregulating short stature homeobox 2 expression. This finding provides new insights into the role of KIF9-AS1 in HCC pathogenesis and highlights its potential as a biomarker and therapeutic target.
Publish Date	2024-11-29 08:40
Citation	<p>Yu Y, Lu XH, Mu JS, Meng JY, Sun JS, Chen HX, Yan Y, Meng K. N6-methyladenosine-modified long non-coding RNA KIF9-AS1 promotes stemness and sorafenib resistance in hepatocellular carcinoma by upregulating SHOX2 expression. <i>World J Gastroenterol</i> 2024; 30(48): 5174-5190</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i48/5174.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i48.5174

Full Article (PDF)	WJG-30-5174-with-cover.pdf
The ARRIVE Guidelines	98208-The-ARRIVE-Guidelines.pdf
Manuscript File	98208_Auto_Edited_023155.docx
Answering Reviewers	98208-answering-reviewers.pdf
Audio Core Tip	98208-audio.MP3
Biostatistics Review Certificate	98208-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98208-conflict-of-interest-statement.pdf
Copyright License Agreement	98208-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98208-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	98208-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	98208-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	98208-non-native-speakers.pdf
Peer-review Report	98208-peer-reviews.pdf
Scientific Misconduct Check	98208-scientific-misconduct-check.png
Scientific Editor Work List	98208-scientific-editor-work-list.pdf
CrossCheck Report	98208-crosscheck-report.pdf