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Articles Published Processes
11/29/2024 8:40:09 AM | Browse: 196 | Download: 933
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Received |
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2024-06-20 11:00 |
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Peer-Review Started |
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2024-06-20 11:00 |
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First Decision by Editorial Office Director |
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2024-09-16 04:53 |
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Return for Revision |
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2024-09-16 04:53 |
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Revised |
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2024-09-26 07:36 |
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Publication Fee Transferred |
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2024-11-11 13:50 |
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Second Decision by Editor |
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2024-11-08 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-11-08 06:42 |
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Articles in Press |
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2024-11-08 06:42 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-11-18 02:19 |
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Publish the Manuscript Online |
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2024-11-29 08:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
N6-methyladenosine-modified long non-coding RNA KIF9-AS1 promotes stemness and sorafenib resistance in hepatocellular carcinoma by upregulating SHOX2 expression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yong Yu, Xiang-Hong Lu, Jin-Song Mu, Jiang-Yun Meng, Jiang-Shan Sun, Hai-Xu Chen, Yang Yan and Ke Meng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82271628 |
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| Corresponding Author |
Ke Meng, MD, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese People’s Liberation Army General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. mengke301@126.com |
| Key Words |
Hepatocellular carcinoma; Stemness; Sorafenib resistance; Long non-coding RNA KIF9-AS1; Short stature homeobox 2 |
| Core Tip |
Hepatocellular carcinoma (HCC) is a highly aggressive tumor with a poor prognosis. Our previous investigation revealed that knockdown of the long non-coding RNA KIF9-AS1 suppressed HCC progression. However, the role of KIF9-AS1 in cancer stemness and drug resistance in HCC remains unclear. This study revealed that N6-methyladenosine modification of KIF9-AS1 promotes stemness and sorafenib resistance in HCC by upregulating short stature homeobox 2 expression. This finding provides new insights into the role of KIF9-AS1 in HCC pathogenesis and highlights its potential as a biomarker and therapeutic target. |
| Publish Date |
2024-11-29 08:40 |
| Citation |
Yu Y, Lu XH, Mu JS, Meng JY, Sun JS, Chen HX, Yan Y, Meng K. N6-methyladenosine-modified long non-coding RNA KIF9-AS1 promotes stemness and sorafenib resistance in hepatocellular carcinoma by upregulating SHOX2 expression. World J Gastroenterol 2024; 30(48): 5174-5190
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| URL |
https://www.wjgnet.com/1007-9327/full/v30/i48/5174.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i48.5174 |
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