| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Retrospective Study |
| Article Title |
Effect of frailty as measured by functional impairment on long-term outcomes in liver transplantation in the United States
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Julius Balogh, Talha Mubashir, Yuan Li, Biai D Digbeu, Nikita Hegde, Fatemeh Movaghari Pour, Mohsen Rezapour, Hong-yin Lai, Kelly West, Rabail A Chaudhry, George W Williams and Vahed Maroufy |
| ORCID |
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| Funding Agency and Grant Number |
|
| Corresponding Author |
Vahed Maroufy, Assistant Professor, PhD, Department of Biostatistics and Data Science, The University of Texas Health Center at Houston School of Public Health, 1200 Pressler Street, Houston, TX 77030, United States. vahed.maroufy@uth.tmc.edu |
| Key Words |
Non-alcoholic steatotic liver disease; Alcohol-associated liver disease; Liver transplantation; Non-alcoholic steatohepatitis; Insulin resistance; Oxidative stress |
| Core Tip |
In this study, we utilized an updated Karnofsky Performance Score, and intentionally converted the frailty assessment binary (frail vs non-frail) and enhancing reliability over more nuanced frailty assessments. Our study observed that frail recipients had significantly higher post-transplant mortality at 12 months, a critical period when transplant centers' monitoring traditionally wanes. Moreover, our study also showed a declining trend of the association between the model for end-stage liver disease score and post-transplant mortality, but an increasing trend between frailty and post-transplant mortality, from 1 month to 12 months post-transplant. |
| Publish Date |
2025-02-21 10:12 |
| Citation |
Balogh J, Mubashir T, Li Y, Digbeu BD, Hegde N, Pour FM, Rezapour M, Lai HY, West K, Chaudhry RA, Williams GW, Maroufy V. Effect of frailty as measured by functional impairment on long-term outcomes in liver transplantation in the United States. World J Transplant 2025; 15(2): 98228 |
| URL |
https://www.wjgnet.com/2220-3230/full/v15/i2/98228.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v15.i2.98228 |
