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11/17/2014 3:13:00 PM | Browse: 749 | Download: 945
Publication Name World Journal of Gastroenterology
Manuscript ID 9823
Country/Territory Spain
2014-03-01 13:45
Peer-Review Started
2014-03-01 20:22
To Make the First Decision
2014-04-15 19:48
Return for Revision
2014-04-19 21:04
2014-05-04 00:00
Second Decision
2014-06-23 10:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-23 10:17
Articles in Press
2014-06-23 10:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-11-02 17:44
Publish the Manuscript Online
2014-11-17 15:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Topic Highlights
Article Title Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics
Manuscript Source Invited Manuscript
All Author List Julio Plaza-Diaz, Carolina Gomez-Llorente, Luis Fontana and Angel Gil
Funding Agency and Grant Number
Corresponding author Angel Gil, PhD, Professor, Department of Biochemistry and Molecular Biology II, School of Pharmacy and Institute of Nutrition and Food Technology “Jose Mataix”, Biomedical Research Center, University of Granada, Avenida del Conocimiento s/n, 18100 Armilla, Granada, Spain. agil@ugr.es
Key Words Gene expression; Immunity; Immunotolerance; Inflammation; Microbiota; Probiotics; Gut; Liver
Core Tip Probiotics, which include live microorganisms as well as dead bacteria and bacterial molecular components, confer a health benefit to the host when administered in adequate amounts. Most of the published research articles that are devoted to probiotics evaluate the effects of probiotics on the prevention and treatment of diseases. However, only a few of these articles address the mechanism of action of these microorganisms. This paper reviews the mechanisms of action that have been proposed to explain the beneficial effects of probiotics, most of which involve gene expression regulation in specific tissues, particularly the intestine and liver. Several strains of Lactic acid bacteria, Escherichia coli, Propionibacterium, Bacillus and Saccharomyces influence the gene expression in gut and liver cells, leading mainly to anti-inflammatory responses and to the enhancement of immunotolerance to foreign antigens.
Publish Date 2014-11-17 15:12
Citation Plaza-Diaz J, Gomez-Llorente C, Fontana L, Gil A. Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics. World J Gastroenterol 2014; 20(42): 15632-15649
Url http://www.wjgnet.com/1007-9327/full/v20/i42/15632.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i42.15632
Full Article (PDF) WJG-20-15632.pdf
Full Article (Word) WJG-20-15632.doc
Manuscript File 9823-Review.doc
Answering Reviewers 9823-Answering reviewers.pdf
Copyright License Agreement 9823-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 9823-Language certificate.pdf
Peer-review Report 9823-Peer review.pdf
Scientific Misconduct Check 9823-CorssCheck.jpg
Scientific Editor Work List 9823-Scientific editor work list.pdf