Publication Name	World Journal of Gastroenterology
Manuscript ID	9823
Country	Spain

Received	2014-03-01 13:45
Peer-Review Started	2014-03-01 20:22
To Make the First Decision	2014-04-15 19:48
Return for Revision	2014-04-19 21:04
Revised	2014-05-04 00:00
Second Decision	2014-06-23 10:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-23 10:17
Articles in Press	2014-06-23 10:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-02 17:44
Publish the Manuscript Online	2014-11-17 15:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics
Manuscript Source	Invited Manuscript
All Author List	Julio Plaza-Diaz, Carolina Gomez-Llorente, Luis Fontana and Angel Gil
Funding Agency and Grant Number
Corresponding Author	Angel Gil, PhD, Professor, Department of Biochemistry and Molecular Biology II, School of Pharmacy and Institute of Nutrition and Food Technology “Jose Mataix”, Biomedical Research Center, University of Granada, Avenida del Conocimiento s/n, 18100 Armilla, Granada, Spain. agil@ugr.es
Key Words	Gene expression; Immunity; Immunotolerance; Inflammation; Microbiota; Probiotics; Gut; Liver
Core Tip	Probiotics, which include live microorganisms as well as dead bacteria and bacterial molecular components, confer a health benefit to the host when administered in adequate amounts. Most of the published research articles that are devoted to probiotics evaluate the effects of probiotics on the prevention and treatment of diseases. However, only a few of these articles address the mechanism of action of these microorganisms. This paper reviews the mechanisms of action that have been proposed to explain the beneficial effects of probiotics, most of which involve gene expression regulation in specific tissues, particularly the intestine and liver. Several strains of Lactic acid bacteria, Escherichia coli, Propionibacterium, Bacillus and Saccharomyces influence the gene expression in gut and liver cells, leading mainly to anti-inflammatory responses and to the enhancement of immunotolerance to foreign antigens.
Publish Date	2014-11-17 15:12
Citation	Plaza-Diaz J, Gomez-Llorente C, Fontana L, Gil A. Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics. World J Gastroenterol 2014; 20(42): 15632-15649
URL	http://www.wjgnet.com/1007-9327/full/v20/i42/15632.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i42.15632

Full Article (PDF)	WJG-20-15632.pdf
Full Article (Word)	WJG-20-15632.doc
Manuscript File	9823-Review.doc
Answering Reviewers	9823-Answering reviewers.pdf
Copyright License Agreement	9823-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9823-Language certificate.pdf
Peer-review Report	9823-Peer review.pdf
Scientific Misconduct Check	9823-CorssCheck.jpg
Scientific Editor Work List	9823-Scientific editor work list.pdf