Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	98243
Country	China

Received	2024-06-21 06:22
Peer-Review Started	2024-06-21 06:22
To Make the First Decision
Return for Revision	2024-07-13 05:46
Revised	2024-07-19 01:43
Second Decision	2024-07-30 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-30 06:26
Articles in Press	2024-07-30 06:26
Publication Fee Transferred	2024-07-31 00:26
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-08-19 06:05
Publish the Manuscript Online	2024-09-09 08:41

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Prognostic value of PEA3 subfamily gene expression in cholangiocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Li Wang, Zhe Zhang and Hai-Zhang Ma
ORCID	Author(s) ORCID Number Li Wang http://orcid.org/0000-0002-3356-0704 Zhe Zhang http://orcid.org/0009-0009-4009-2396
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Development Plan Project of Hangzhou No. 20201203B56
Corresponding Author	Zhe Zhang, Doctor, Doctor, Doctor, Department of Emergency Medicine, The First People’s Hospital of Linping District Hangzhou, No. 369 Yingbin Road, Nanyuan Street, Linping District, Hangzhou 311100, Zhejiang Province, China. zz2516116@163.com
Key Words	PEA3 subfamily; Cholangiocarcinoma; The cancer genome atlas; ETV4; The prognosis; Prognostic biomarker
Core Tip	This study investigates the expression of the PEA3 subfamily genes (ETV1, ETV4, ETV5) in cholangiocarcinoma (CCA) and their clinical relevance. Using data from cancer genome atlas and genotype-tissue expression project databases, we identified significantly elevated levels of ETV1, ETV4 and ETV5 in CCA. High expression of ETV1 and ETV4 was explicitly correlated with shorter overall survival in CCA patients. Functional assays demonstrated that silencing PEA3 genes reduces invasion and metastasis in CCA cells in vitro and in vivo. These findings suggest that ETV4 may be a valuable prognostic biomarker for survival of CCA patients.
Publish Date	2024-09-09 08:41
Citation	<p>Wang L, Zhang Z, Ma HZ. Prognostic value of PEA3 subfamily gene expression in cholangiocarcinoma. <i>World J Gastrointest Oncol</i> 2024; 16(9): 4014-4027</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i9/4014.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i9.4014

Full Article (PDF)	WJGO-16-4014-with-cover.pdf
The ARRIVE Guidelines	98243-The-ARRIVE-Guidelines.pdf
Manuscript File	98243_Auto_Edited_072501.docx
Answering Reviewers	98243-answering-reviewers.pdf
Audio Core Tip	98243-audio.mp3
Biostatistics Review Certificate	98243-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98243-conflict-of-interest-statement.pdf
Copyright License Agreement	98243-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98243-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	98243-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	98243-non-native-speakers.pdf
Peer-review Report	98243-peer-reviews.pdf
Scientific Misconduct Check	98243-scientific-misconduct-check.png
Scientific Editor Work List	98243-scientific-editor-work-list.pdf
CrossCheck Report	98243-crosscheck-report.png
CrossCheck Report	98243-crosscheck-report.pdf