Publication Name	World Journal of Gastroenterology
Manuscript ID	98250
Country	India

Received	2024-06-21 11:25
Peer-Review Started	2024-06-21 11:25
To Make the First Decision
Return for Revision	2024-08-13 19:36
Revised	2024-09-06 02:39
Second Decision	2024-09-11 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-11 06:02
Articles in Press	2024-09-11 06:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-18 03:22
Publish the Manuscript Online	2024-09-26 08:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Critical analysis of the effects of proton pump inhibitors on inflammatory bowel disease: An updated review
Manuscript Source	Invited Manuscript
All Author List	Omesh Goyal and Manjeet Kumar Goyal
ORCID	Author(s) ORCID Number Omesh Goyal http://orcid.org/0000-0002-6347-0988 Manjeet Kumar Goyal http://orcid.org/0000-0002-5511-2099
Funding Agency and Grant Number
Corresponding Author	Omesh Goyal, DM, MBBS, MD, Professor, Department of Gastroenterology, Dayanand Medical College and Hospital, Civil Lines, Ludhiana 141001, Punjab, India. dromeshgoyal@gmail.com
Key Words	Proton pump inhibitors; Inflammatory bowel disease; Gut microbiota; Intestinal mucosal barrier; Immune cell function
Core Tip	This letter critically analyzes the review by Liang et al on the effects of proton pump inhibitors (PPIs) on inflammatory bowel disease (IBD), highlighting several methodological flaws. Reliance on cross-sectional and observational studies limits causal inference, and heterogeneous study populations complicate result interpretation. Furthermore, inconsistent definitions of long-term PPI use, inadequate control for confounding factors, and potential publication bias necessitate cautious interpretation. Future research should prioritize large-scale, prospective cohort studies with rigorous control for confounders, standardized outcome measures, and transparent study selection criteria. Addressing these issues is essential for guiding clinical practice effectively and improving outcomes in IBD management.
Publish Date	2024-09-26 08:22
Citation	<p>Goyal O, Goyal MK. Critical analysis of the effects of proton pump inhibitors on inflammatory bowel disease: An updated review. <i>World J Gastroenterol</i> 2024; 30(37): 4160-4162</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i37/4160.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i37.4160

Full Article (PDF)	WJG-30-4160-with-cover.pdf
Manuscript File	98250_Auto_Edited_061720.docx
Answering Reviewers	98250-answering-reviewers.pdf
Audio Core Tip	98250-audio.mp3
Conflict-of-Interest Disclosure Form	98250-conflict-of-interest-statement.pdf
Copyright License Agreement	98250-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	98250-non-native-speakers.pdf
Peer-review Report	98250-peer-reviews.pdf
Scientific Misconduct Check	98250-scientific-misconduct-check.png
Scientific Editor Work List	98250-scientific-editor-work-list.pdf
CrossCheck Report	98250-crosscheck-report.pdf