| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Clinical significance of upregulated Rho GTPase activating protein 12 causing resistance to tyrosine kinase inhibitors in hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Wei Wang, Yu-Xing Tang, Fu-Xi Li, Jia-Le Wang, Gao-Peng Yao, Da-Tong Zeng, Yu-Lu Tang, Bang-Teng Chi, Qin-Yan Su, Lin-Qing Huang, Di-Yuan Qin, Gang Chen, Zhen-Bo Feng and Rong-Quan He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82260581 |
| Guangxi Zhuang Autonomous Region Health Committee Scientific Research Project |
Z20201147 |
| Guangxi Medical University Education and Teaching Reform Project |
2021XJGA02 |
| Undergraduate Teaching Reform Project of Guangxi Higher Education |
2023JGB163 |
| Guangxi Medical University Teacher Teaching Ability Development Project |
2202JFA20 |
| China Undergraduate Innovation and Entrepreneurship Training Program |
S202310598170 |
|
| Corresponding Author |
Zhen-Bo Feng, MD, PhD, Professor, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. fengzhenbo_gxmu@163.com |
| Key Words |
Hepatocellular carcinoma; Focal adhesion; Tyrosine kinase inhibitor; Rho GTPase activating protein 12; Drug resistance; Molecular mechanism; Biomarker |
| Core Tip |
Molecular therapy has the potential to reverse tyrosine kinase inhibitors (TKIs) resistance in hepatocellular carcinoma (HCC). We combined 22861 single-cell RNA sequencing malignant cells, 5113 bulk RNA data (bulk RNA-seq and microarrays), and 562 immunohistochemistry samples to explore Rho GTPase activating protein 12 (ARHGAP12) high expression from mRNA and protein. The higher its expression, the worse the prognosis of HCC patients. HCC TKIs showed ARHGAP12 resistance. Mechanistically, we confirmed ARHGAP12 can regulate focal adhesion by combining single-cell RNA sequencing and reconfirmed it from bulk RNA of HCC and HCC TKIs. Drug sensitivity analysis showed that high expression of ARHGAP12 was associated with TKIs resistance, but not with immunotherapy. |
| Publish Date |
2024-09-26 10:17 |
| Citation |
Wang XW, Tang YX, Li FX, Wang JL, Yao GP, Zeng DT, Tang YL, Chi BT, Su QY, Huang LQ, Qin DY, Chen G, Feng ZB, He RQ. Clinical significance of upregulated Rho GTPase activating protein 12 causing resistance to tyrosine kinase inhibitors in hepatocellular carcinoma. World J Gastrointest Oncol 2024; 16(10): 4244-4263 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i10/4244.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i10.4244 |
