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1/20/2025 2:39:06 AM | Browse: 45 | Download: 209
Publication Name World Journal of Stem Cells
Manuscript ID 98349
Country China
Received
2024-07-02 01:13
Peer-Review Started
2024-07-02 01:13
To Make the First Decision
Return for Revision
2024-09-24 08:54
Revised
2024-10-02 08:31
Second Decision
2024-11-28 02:10
Accepted by Journal Editor-in-Chief
2024-12-03 07:44
Accepted by Executive Editor-in-Chief
2024-12-10 06:53
Articles in Press
2024-12-10 06:53
Publication Fee Transferred
2024-12-10 10:15
Edit the Manuscript by Language Editor
2024-12-21 00:54
Typeset the Manuscript
2025-01-07 00:57
Publish the Manuscript Online
2025-01-20 02:39
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell & Tissue Engineering
Manuscript Type Basic Study
Article Title Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models
Manuscript Source Unsolicited Manuscript
All Author List Jing Yang, Jun Yuan, Yan-Qing Wen, Li Wu, Jiu-Jiang Liao and Hong-Bo Qi
ORCID
Author(s) ORCID Number
Jiu-Jiang Liao http://orcid.org/0009-0006-1855-1689
Hong-Bo Qi http://orcid.org/0000-0002-4911-7942
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 82301919
China Postdoctoral Science Foundation 2023M730441
Guizhou Provincial Science and Technology Projects [2020]1Y149
Joint Funds of the National Natural Science Foundation of China U21A20346
Key Research Program of Chongqing Science and Technology Bureau CSTB2022TIAD-KPX0156
Corresponding Author Hong-Bo Qi, MD, PhD, Professor, /, Women and Children’s Hospital of Chongqing Medical University, No. 120 Longshan Road, Yubei District, Chongqing 401147, China. qihongbo@cqmu.edu.cn
Key Words Uterine injury; Bone marrow mesenchymal stem cells; Uterine smooth muscle cells; Phosphatidylinositol 3-kinase/protein kinase B pathway; Cell-cell interactions; Cell proliferation; Immune regulation; Wound regeneration
Core Tip We identified differentially genes in uterine wound tissues through transcriptome sequencing. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed that regeneration and anti-inflammatory factors were upregulated in bone mesenchymal stem cell (BMSCs) groups and that the phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin pathway was highly enriched. This study also demonstrated that BMSCs significantly promoted the proliferation and migration of uterine smooth muscle cells (USMCs) and that USMCs enhanced the myogenic differentiation of BMSCs. In vivo and in vitro experiments have shown that BMSCs activate the phosphatidylinositol 3-kinase/protein kinase B pathway in wound tissues and USMCs.
Publish Date 2025-01-20 02:39
Citation <p>Yang J, Yuan J, Wen YQ, Wu L, Liao JJ, Qi HB. Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models. <i>World J Stem Cells</i> 2025; 17(1): 98349</p>
URL https://www.wjgnet.com/1948-0210/full/v17/i1/98349.htm
DOI https://dx.doi.org/10.4252/wjsc.v17.i1.98349
Full Article (PDF) WJSC-17-98349-with-cover.pdf
The ARRIVE Guidelines 98349-The-ARRIVE-Guidelines.pdf
Manuscript File 98349_Auto_Edited_011935.docx
Answering Reviewers 98349-answering-reviewers.pdf
Audio Core Tip 98349-audio.mp3
Biostatistics Review Certificate 98349-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 98349-conflict-of-interest-statement.pdf
Copyright License Agreement 98349-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 98349-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 98349-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate 98349-non-native-speakers.pdf
Peer-review Report 98349-peer-reviews.pdf
Journal Editor-in-Chief Review Report 98349-journal-editor-in-chief.pdf
Scientific Misconduct Check 98349-scientific-misconduct-check.png
Scientific Editor Work List 98349-scientific-editor-work-list.pdf
CrossCheck Report 98349-crosscheck-report.pdf