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Articles Published Processes
1/20/2025 2:39:06 AM | Browse: 45 | Download: 209
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Received |
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2024-07-02 01:13 |
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Peer-Review Started |
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2024-07-02 01:13 |
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To Make the First Decision |
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Return for Revision |
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2024-09-24 08:54 |
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Revised |
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2024-10-02 08:31 |
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Second Decision |
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2024-11-28 02:10 |
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Accepted by Journal Editor-in-Chief |
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2024-12-03 07:44 |
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Accepted by Executive Editor-in-Chief |
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2024-12-10 06:53 |
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Articles in Press |
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2024-12-10 06:53 |
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Publication Fee Transferred |
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2024-12-10 10:15 |
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Edit the Manuscript by Language Editor |
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2024-12-21 00:54 |
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Typeset the Manuscript |
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2025-01-07 00:57 |
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Publish the Manuscript Online |
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2025-01-20 02:39 |
ISSN |
1948-0210 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Cell & Tissue Engineering |
Manuscript Type |
Basic Study |
Article Title |
Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Jing Yang, Jun Yuan, Yan-Qing Wen, Li Wu, Jiu-Jiang Liao and Hong-Bo Qi |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
82301919 |
China Postdoctoral Science Foundation |
2023M730441 |
Guizhou Provincial Science and Technology Projects |
[2020]1Y149 |
Joint Funds of the National Natural Science Foundation of China |
U21A20346 |
Key Research Program of Chongqing Science and Technology Bureau |
CSTB2022TIAD-KPX0156 |
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Corresponding Author |
Hong-Bo Qi, MD, PhD, Professor, /, Women and Children’s Hospital of Chongqing Medical University, No. 120 Longshan Road, Yubei District, Chongqing 401147, China. qihongbo@cqmu.edu.cn |
Key Words |
Uterine injury; Bone marrow mesenchymal stem cells; Uterine smooth muscle cells; Phosphatidylinositol 3-kinase/protein kinase B pathway; Cell-cell interactions; Cell proliferation; Immune regulation; Wound regeneration |
Core Tip |
We identified differentially genes in uterine wound tissues through transcriptome sequencing. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed that regeneration and anti-inflammatory factors were upregulated in bone mesenchymal stem cell (BMSCs) groups and that the phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin pathway was highly enriched. This study also demonstrated that BMSCs significantly promoted the proliferation and migration of uterine smooth muscle cells (USMCs) and that USMCs enhanced the myogenic differentiation of BMSCs. In vivo and in vitro experiments have shown that BMSCs activate the phosphatidylinositol 3-kinase/protein kinase B pathway in wound tissues and USMCs. |
Publish Date |
2025-01-20 02:39 |
Citation |
<p>Yang J, Yuan J, Wen YQ, Wu L, Liao JJ, Qi HB. Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models. <i>World J Stem Cells</i> 2025; 17(1): 98349</p> |
URL |
https://www.wjgnet.com/1948-0210/full/v17/i1/98349.htm |
DOI |
https://dx.doi.org/10.4252/wjsc.v17.i1.98349 |
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