Publication Name	World Journal of Stem Cells
Manuscript ID	98349
Country	China

Received	2024-07-02 01:13
Peer-Review Started	2024-07-02 01:13
To Make the First Decision
Return for Revision	2024-09-24 08:54
Revised	2024-10-02 08:31
Second Decision	2024-11-28 02:10
Accepted by Journal Editor-in-Chief	2024-12-03 07:44
Accepted by Executive Editor-in-Chief	2024-12-10 06:53
Articles in Press	2024-12-10 06:53
Publication Fee Transferred	2024-12-10 10:15
Edit the Manuscript by Language Editor	2024-12-21 00:54
Typeset the Manuscript	2025-01-07 00:57
Publish the Manuscript Online	2025-01-20 02:39

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models
Manuscript Source	Unsolicited Manuscript
All Author List	Jing Yang, Jun Yuan, Yan-Qing Wen, Li Wu, Jiu-Jiang Liao and Hong-Bo Qi
ORCID	Author(s) ORCID Number Jiu-Jiang Liao http://orcid.org/0009-0006-1855-1689 Hong-Bo Qi http://orcid.org/0000-0002-4911-7942
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82301919 China Postdoctoral Science Foundation 2023M730441 Guizhou Provincial Science and Technology Projects [2020]1Y149 Joint Funds of the National Natural Science Foundation of China U21A20346 Key Research Program of Chongqing Science and Technology Bureau CSTB2022TIAD-KPX0156
Corresponding Author	Hong-Bo Qi, MD, PhD, Professor, /, Women and Children’s Hospital of Chongqing Medical University, No. 120 Longshan Road, Yubei District, Chongqing 401147, China. qihongbo@cqmu.edu.cn
Key Words	Uterine injury; Bone marrow mesenchymal stem cells; Uterine smooth muscle cells; Phosphatidylinositol 3-kinase/protein kinase B pathway; Cell-cell interactions; Cell proliferation; Immune regulation; Wound regeneration
Core Tip	We identified differentially genes in uterine wound tissues through transcriptome sequencing. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed that regeneration and anti-inflammatory factors were upregulated in bone mesenchymal stem cell (BMSCs) groups and that the phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin pathway was highly enriched. This study also demonstrated that BMSCs significantly promoted the proliferation and migration of uterine smooth muscle cells (USMCs) and that USMCs enhanced the myogenic differentiation of BMSCs. In vivo and in vitro experiments have shown that BMSCs activate the phosphatidylinositol 3-kinase/protein kinase B pathway in wound tissues and USMCs.
Publish Date	2025-01-20 02:39
Citation	<p>Yang J, Yuan J, Wen YQ, Wu L, Liao JJ, Qi HB. Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models. <i>World J Stem Cells</i> 2025; 17(1): 98349</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i1/98349.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i1.98349

Full Article (PDF)	WJSC-17-98349-with-cover.pdf
The ARRIVE Guidelines	98349-The-ARRIVE-Guidelines.pdf
Manuscript File	98349_Auto_Edited_011935.docx
Answering Reviewers	98349-answering-reviewers.pdf
Audio Core Tip	98349-audio.mp3
Biostatistics Review Certificate	98349-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98349-conflict-of-interest-statement.pdf
Copyright License Agreement	98349-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98349-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	98349-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	98349-non-native-speakers.pdf
Peer-review Report	98349-peer-reviews.pdf
Journal Editor-in-Chief Review Report	98349-journal-editor-in-chief.pdf
Scientific Misconduct Check	98349-scientific-misconduct-check.png
Scientific Editor Work List	98349-scientific-editor-work-list.pdf
CrossCheck Report	98349-crosscheck-report.pdf