Publication Name	World Journal of Stem Cells
Manuscript ID	98351
Country	China

Received	2024-08-20 08:16
Peer-Review Started	2024-08-20 08:16
To Make the First Decision
Return for Revision	2024-09-06 10:16
Revised	2024-10-09 13:07
Second Decision	2024-11-05 02:42
Accepted by Journal Editor-in-Chief	2024-11-06 06:09
Accepted by Executive Editor-in-Chief	2024-11-29 08:12
Articles in Press	2024-11-29 08:12
Publication Fee Transferred	2024-12-01 12:47
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-09 08:25
Publish the Manuscript Online	2024-12-13 03:22

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Preliminary study on the preparation of lyophilized acellular nerve scaffold complexes from rabbit sciatic nerves with human umbilical cord mesenchymal stem cells
Manuscript Source	Unsolicited Manuscript
All Author List	Chuang Qian, Shang-Yu Guo, Zheng Xu, Zhi-Qiang Zhang, Hao-Dong Li, Hao Li and Xiong-Sheng Chen
ORCID	Author(s) ORCID Number Hao Li http://orcid.org/0000-0001-7755-1749
Funding Agency and Grant Number
Corresponding Author	Hao Li, PhD, Department of Neurosurgery, Children’s Hospital of Fudan University & National Children’s Medical Center, No. 399 Wanyuan Road, Minghang District, Shanghai 201102, China. lihao7272@163.com
Key Words	Human umbilical cord mesenchymal stem cells; Peripheral nerve injury; Schwann cells; Acellular nerve scaffolds
Core Tip	The treatment of severe peripheral nerve injuries remains a clinical challenge, particularly in children. Autologous nerve grafts are the standard treatment for these severe neurologic deficits and the scarce number of autologous nerves and the loss of neurosensory function in the donor area are major obstacles, particularly in infants and young children. Allogeneic or xenografts are even more limited by immune rejection. Therefore, there is an urgent need for a peripheral nerve substitute that can bridge the two severed ends of the nerve, guide its axonal growth to avoid the formation of neuroma, and promote and guide the functional regeneration of the peripheral nerve. For patients with neonatal brachial plexus injury, human umbilical cord mesenchymal stem cells (hUC-MSCs) are an effective tool. In this study, we proposed to culture hUC-MSCs as seed cells on suitable decellularized scaffolds.
Publish Date	2024-12-13 03:22
Citation	<p>Qian C, Guo SY, Xu Z, Zhang ZQ, Li HD, Li H, Chen XS. Preliminary study on the preparation of lyophilized acellular nerve scaffold complexes from rabbit sciatic nerves with human umbilical cord mesenchymal stem cells. <i>World J Stem Cells</i> 2024; 16(12): 1047-1061</p>
URL	https://www.wjgnet.com/1948-0210/full/v16/i12/1047.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i12.1047

Full Article (PDF)	WJSC-16-1047-with-cover.pdf
The ARRIVE Guidelines	98351-The-ARRIVE-Guidelines.pdf
Manuscript File	98351_Auto_Edited_014026.docx
Answering Reviewers	98351-answering-reviewers.pdf
Audio Core Tip	98351-audio.mp3
Biostatistics Review Certificate	98351-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98351-conflict-of-interest-statement.pdf
Copyright License Agreement	98351-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	98351-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	98351-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	98351-non-native-speakers.pdf
Peer-review Report	98351-peer-reviews.pdf
Journal Editor-in-Chief Review Report	98351-journal-editor-in-chief.pdf
Scientific Misconduct Check	98351-scientific-misconduct-check.png
Scientific Editor Work List	98351-scientific-editor-work-list.pdf
CrossCheck Report	98351-crosscheck-report.png
CrossCheck Report	98351-crosscheck-report.pdf