| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Basic Study |
| Article Title |
Correlations of the expression of Cx43, SCFFBXW7, p-cyclin E1 (Ser73), p-cyclin E1 (Thr77) and p-cyclin E1 (Thr395) in colon cancer tissues
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rong-Gang Luan, Ming-Da Liu, Zi-Feng Deng, Cong-Lan Lu, Mei-Ling Yu, Ming-Yu Zhang, Rong Liu, Ran An, You-Liang Yao, Dong-Bei Guo, Yong-Xing Zhang and Lei Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Innovative Practice Platform for Undergraduate Students, School of public Health Xiamen University |
2021001 |
|
| Corresponding Author |
Lei Zhao, MD, PhD, Department of Orthopaedics, Air Force Hospital of Eastern Theater, Anhui Medical University, No. 1 Changfu Road, Nanjing 230032, Jiangsu Province, China. 18742583975@163.com |
| Key Words |
Colon cancer; Cx43; SCFFBXW7; Phosphorylation of cyclin E1; Sites of cyclin E1; Correlation analysis |
| Core Tip |
In this study, we found that SKP1/Cullin1/F-box (SCF)FBXW7 exhibited a positive correlation with cyclin E1 expression at positions ser73 and thr395 in colon cancer tissues, suggesting that SCFFBXW7 may facilitate phosphorylation-dependent degradation by interacting with cyclin E1 at these specific sites. Furthermore, the expressions of Cx43 and SCFFBXW7 were positively correlated, as well as their association with the levels at positions ser73 and thr395. This indicates that Cx43 may enhance the phosphorylation of these two sites through its interaction with SCFFBXW7, thereby promoting the ubiquitination and degradation of cyclin E1. |
| Publish Date |
2024-12-12 09:30 |
| Citation |
<p>Luan RG, Liu MD, Deng ZF, Lu CL, Yu ML, Zhang MY, Liu R, An R, Yao YL, Guo DB, Zhang YX, Zhao L. Correlations of the expression of Cx43, SCFFBXW7, p-cyclin E1 (Ser73), p-cyclin E1 (Thr77) and p-cyclin E1 (Thr395) in colon cancer tissues. <i>World J Gastrointest Oncol</i> 2025; 17(1): 98410</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i1/98410.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i1.98410 |
