Publication Name	World Journal of Diabetes
Manuscript ID	98423
Country	China

Received	2024-06-26 04:10
Peer-Review Started	2024-06-26 04:10
To Make the First Decision
Return for Revision	2024-10-10 07:38
Revised	2024-10-22 05:43
Second Decision	2024-11-15 16:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-05 07:32
Articles in Press	2024-12-05 07:32
Publication Fee Transferred	2024-12-05 09:23
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-20 00:09
Publish the Manuscript Online	2024-12-30 09:47

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Clinical significance of Ki-67 in patients with lung adenocarcinoma in situ complicated by type 2 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Ke Chen, Ge Wang, Jing-Cheng Hu, Ying-Yi Zhou and Hai-Tao Ma
ORCID	Author(s) ORCID Number Ke Chen http://orcid.org/0000-0002-4719-491X Jing-Cheng Hu http://orcid.org/0000-0003-2747-5885 Ying-Yi Zhou http://orcid.org/0000-0003-3673-8309 Hai-Tao Ma http://orcid.org/0000-0002-9107-2928
Funding Agency and Grant Number
Corresponding Author	Hai-Tao Ma, Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, No. 188 Shizi Road, Suzhou 215000, Jiangsu Province, China. htma_work@163.com
Key Words	Ki-67; Type 2 diabetes mellitus; Lung adenocarcinoma in situ; Immunohistochemistry; Prognostic marker
Core Tip	Type 2 diabetes mellitus (T2DM) is an independent risk factor for lung cancer and increases mortality risk; Ki-67, a proliferation marker, is highly expressed in lung cancer, especially with T2DM; elevated Ki-67 levels in adenocarcinoma in situ (AIS) patients with T2DM suggest its utility as a screening marker. Hyperglycemia and insulin resistance in T2DM may drive cancer progression via the Ras/MAPK and IGF-1 signaling pathways. Regular monitoring of Ki-67, glycosylated hemoglobin, and lipid levels is essential for early detection and better prognosis in patients with AIS and T2DM.
Publish Date	2024-12-30 09:47
Citation	<p>Chen K, Wang G, Hu JC, Zhou YY, Ma HT. Clinical significance of Ki-67 in patients with lung adenocarcinoma in situ complicated by type 2 diabetes. <i>World J Diabetes</i> 2025; 16(2): 98423</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i2/98423.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i2.98423

Full Article (PDF)	WJD-16-98423-with-cover.pdf
STROBE Statement	98423-STROBE-statement.pdf
Manuscript File	98423_Auto_Edited_014503.docx
Answering Reviewers	98423-answering-reviewers.pdf
Audio Core Tip	98423-audio.m4a
Biostatistics Review Certificate	98423-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98423-conflict-of-interest-statement.pdf
Copyright License Agreement	98423-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	98423-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	98423-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	98423-non-native-speakers.pdf
Peer-review Report	98423-peer-reviews.pdf
Scientific Misconduct Check	98423-scientific-misconduct-check.png
Scientific Editor Work List	98423-scientific-editor-work-list.pdf
CrossCheck Report	98423-crosscheck-report.pdf