| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Effectiveness of biologics for endoscopic healing in patients with isolated proximal small bowel Crohn’s disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Cheng Huang, Bi-Yao Wang, Bo Peng, Zhong-Cheng Liu, Hui-Xian Lin, Qing-Fan Yang, Jian Tang, Kang Chao, Miao Li, Xiang Gao and Qin Guo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Program of Guangdong Provincial Clinical Research Center for Digestive Diseases |
2020B1111170004 |
|
| Corresponding Author |
Qin Guo, PhD, Professor, Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, No. 26 Erheng Road, Yuancun, Tianhe District, Guangzhou 510000, Guangdong Province, China. guoq83@mail.sysu.edu.cn |
| Key Words |
Crohn’s disease; Isolated proximal small bowel disease; Endoscopic healing; Biologics; Balloon-assisted enteroscopy |
| Core Tip |
Endoscopic healing (EH) is a key treatment target for Crohn’s disease (CD), but limited data are available on isolated proximal small bowel (SB) disease. This retrospective study analyzed the data of patients with isolated proximal SB CD identified through balloon-assisted enteroscopy. We aimed to evaluate the effectiveness of biologics for EH in patients with jejunal and proximal ileal CD at 1 year. The results showed that 20.9% of patients achieved complete EH after 1-year biologic therapy. Failure to achieve complete EH was significantly associated with stricturing or penetrating disease, prior exposure to biologics, and moderate-to-severe endoscopic disease. |
| Publish Date |
2025-01-20 07:38 |
| Citation |
<p>Huang ZC, Wang BY, Peng B, Liu ZC, Lin HX, Yang QF, Tang J, Chao K, Li M, Gao X, Guo Q. Effectiveness of biologics for endoscopic healing in patients with isolated proximal small bowel Crohn’s disease. <i>World J Gastroenterol</i> 2025; 31(7): 98448</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i7/98448.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i7.98448 |
