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Articles Published Processes
11/29/2024 2:50:18 PM | Browse: 123 | Download: 630
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Received |
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2024-06-27 23:59 |
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Peer-Review Started |
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2024-06-27 23:59 |
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First Decision by Editorial Office Director |
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2024-08-18 20:24 |
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Return for Revision |
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2024-08-18 20:24 |
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Revised |
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2024-08-22 08:48 |
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Publication Fee Transferred |
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2024-09-13 09:17 |
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Second Decision by Editor |
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2024-09-13 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-09-13 08:10 |
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Articles in Press |
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2024-09-13 08:10 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-09-29 05:41 |
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Publish the Manuscript Online |
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2024-11-29 14:50 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Ling Yang, Jie Yang, Rong-Fei Fang, Wen-Li Sai, Deng-Fu Yao and Min Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
32470985, 81673241 |
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| Corresponding Author |
Deng-Fu Yao, MD, PhD, Professor, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, No. 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com |
| Key Words |
Angiopoietin-2; Hypoxia-inducible factor-1α; Hepatocarcinogenesis; Dynamic model; Metastasis |
| Core Tip |
In this study, the expression of angiopoietin-2 (Ang-2) in the malignant progression of chronic benign liver diseases was investigated, and its value in monitoring hepatocellular carcinoma (HCC) progression in a dynamic rat model was validated. In a hypoxic environment, Ang-2 activation is associated with the malignant transformation of hepatocytes or the metastasis of HCC cells. Mechanistically, the down-regulation of hypoxia-inducible factor-1α transcription inhibited Ang-2 expression and the epithelial-mesenchymal transition in HCC. These results suggest that there are positive correlations between hypoxia-inducible factor-1α and Ang-2 in benign liver diseases and hepatocyte malignant progression, suggesting that abnormal Ang-2 expression might be a sensitive early biomarker for monitoring the occurrence or metastasis of HCC. |
| Publish Date |
2024-11-29 14:50 |
| Citation |
Yang JL, Yang J, Fang RF, Sai WL, Yao DF, Yao M. Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma. World J Hepatol 2024; 16(12): 1480-1492 |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i12/1480.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i12.1480 |
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