Publication Name	World Journal of Experimental Medicine
Manuscript ID	98525
Country	Grenada

Received	2024-06-28 03:44
Peer-Review Started	2024-06-28 03:44
To Make the First Decision
Return for Revision	2024-07-11 04:39
Revised	2024-07-15 01:02
Second Decision	2024-08-06 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-08-06 07:11
Articles in Press	2024-08-06 07:11
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-08-10 00:27
Typeset the Manuscript	2024-08-15 06:12
Publish the Manuscript Online	2024-08-29 06:31

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Anal carcinoma - exploring the epidemiology, risk factors, pathophysiology, diagnosis, and treatment
Manuscript Source	Invited Manuscript
All Author List	Kevan J English
ORCID	Author(s) ORCID Number Kevan J English http://orcid.org/0009-0006-8893-5696
Funding Agency and Grant Number
Corresponding Author	Kevan J English, MD, Doctor, Doctor, Research Scientist, Department of Medicine, Division of Gastroenterology & Hepatology, Saint George’s University School of Medicine, University Centre, Saint George 33334, Saint George, Grenada. kenglish@sgu.edu
Key Words	Anal cancer; Squamous cell carcinoma; Chemoradiation therapy; Human papillomavirus; Immunosuppression
Core Tip	Anal cancer is a rare malignancy, comprising 1%-6% of anorectal tumors. The incidence of anal carcinoma has been steadily increasing worldwide, and diagnosis is often challenging due to the similarities in clinical presentation to benign rectal diseases such as hemorrhoids. Roughly 85% of anal cancers are squamous cell carcinoma, and human papillomavirus infection and immunosuppression are major risk factors for the disease. Chemoradiation is the treatment of choice for early-stage cancer, while systemic therapy is used for metastatic disease. Novel cytotoxic agents in combination with immunotherapy have produced favorable outcomes in patients with advanced disease.
Publish Date	2024-08-29 06:31
Citation	<p>English KJ. Anal carcinoma - exploring the epidemiology, risk factors, pathophysiology, diagnosis, and treatment. <i>World J Exp Med</i> 2024; 14(3): 98525</p>
URL	https://www.wjgnet.com/2220-315x/full/v14/i3/98525.htm
DOI	https://dx.doi.org/10.5493/wjem.v14.i3.98525

Full Article (PDF)	WJEM-14-98525-with-cover.pdf
Manuscript File	98525_Auto_Edited_071003.docx
Answering Reviewers	98525-answering-reviewers.pdf
Audio Core Tip	98525-audio.m4a
Conflict-of-Interest Disclosure Form	98525-conflict-of-interest-statement.pdf
Copyright License Agreement	98525-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	98525-non-native-speakers.pdf
Peer-review Report	98525-peer-reviews.pdf
Scientific Misconduct Check	98525-scientific-misconduct-check.png
Scientific Editor Work List	98525-scientific-editor-work-list.pdf
CrossCheck Report	98525-crosscheck-report.pdf