| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Bidirectional regulation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ai-Yu Nie, Zhong-Hui Xiao, Jia-Li Deng, Na Li, Li-Yuan Hao, Sheng-Hao Li and Xiao-Yu Hu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81973840 |
| Sichuan Provincial Administration of Traditional Chinese Medicine Major Science and Technology projects |
No. 2021XYCZ004 |
|
| Corresponding Author |
Xiao-Yu Hu, MD, Professor, Department of Infection, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shierqiao Road, Jinniu District, Chengdu 610072, Sichuan Province, China. xiaoyuhu_dr@sina.com |
| Key Words |
Hepatocellular carcinoma; Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene; Interferon genes; The metastasis of a tumor; Immunology |
| Core Tip |
As a crucial signaling pathway for both innate and adaptive immune responses, studies have demonstrated that cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon gene (STING) pathway can be triggered by tumor DNA and genomic instability, thereby promoting or inhibiting tumor development and metastasis. A considerable amount of evidence indicates that the cGAS-STING pathway, as a potential therapeutic target, markedly inhibits tumor cell proliferation and metastasis, with its activation being particularly relevant in hepatocellular carcinoma. But at the same time, prolonged pathway activation may lead to an immunosuppressive tumor microenvironment, fostering liver damage, fibrosis, carcinogenesis, and the invasion or metastasis of liver tumor cells. |
| Publish Date |
2025-01-18 08:12 |
| Citation |
<p>Nie AY, Xiao ZH, Deng JL, Li N, Hao LY, Li SH, Hu XY. Bidirectional regulation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma. <i>World J Gastrointest Oncol</i> 2025; 17(2): 98556</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i2/98556.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i2.98556 |
