Publication Name	World Journal of Orthopedics
Manuscript ID	98609
Country	Italy

Received	2024-06-30 16:52
Peer-Review Started	2024-06-30 16:52
To Make the First Decision
Return for Revision	2024-07-11 04:37
Revised	2024-07-19 12:04
Second Decision	2024-08-05 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-08-05 07:19
Articles in Press	2024-08-05 07:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-08-26 01:32
Publish the Manuscript Online	2024-09-12 12:30

ISSN	2218-5836 (online)
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Category	Orthopedics
Manuscript Type	Systematic Reviews
Article Title	Pain management in acute musculoskeletal injury: Effect of opioid vs nonopioid medications
Manuscript Source	Invited Manuscript
All Author List	Marco Fiore, Luigi Aurelio Nasto, Eleni McCaffery, Fannia Barletta, Angela Visconti, Francesca Gargano, Enrico Pola and Maria Caterina Pace
ORCID	Author(s) ORCID Number Marco Fiore http://orcid.org/0000-0001-7263-0229 Luigi Aurelio Nasto http://orcid.org/0000-0003-3291-9911 Eleni McCaffery http://orcid.org/0009-0002-8336-7803 Fannia Barletta http://orcid.org/0000-0002-1860-6188 Angela Visconti http://orcid.org/0000-0002-4772-2639 Francesca Gargano http://orcid.org/0000-0002-8962-5685 Enrico Pola http://orcid.org/0000-0001-5350-3910 Maria Caterina Pace http://orcid.org/0000-0002-9352-4780
Funding Agency and Grant Number
Corresponding Author	Marco Fiore, MD, Doctor, Doctor, Lecturer, Professor, Department of Women, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Piazza Miraglia 2, Naples 80138, Italy. marco.fiore@unicampania.it
Key Words	Acute musculoskeletal injury; Acute traumatic pain; Non-opioid analgesia; Non-opioid pain control; Opioid-sparing analgesia; Opioid crisis; Opioid disorder; Systematic review
Core Tip	Opioid use is linked to an increased risk of developing opioid use disorder. This systematic review question is “How does the use of opioid medications in pain management, compared with non-opioid medications, affect pain intensity over the short, intermediate, and long-term in adults with acute traumatic pain?”. The search was performed using Medline and Google Scholar. We included 14 studies in the final synthesis [12 were randomized clinical trials (RCTs) and 2 were pseudo-RCTs]. Most retrieved studies on the use of non-opioids concluded that non-opioid drugs are non-inferior to opioids for the control of acute pain in acute musculoskeletal injury.
Publish Date	2024-09-12 12:30
Citation	<p>Fiore M, Nasto LA, McCaffery E, Barletta F, Visconti A, Gargano F, Pola E, Pace MC. Pain management in acute musculoskeletal injury: Effect of opioid vs nonopioid medications. <i>World J Orthop</i> 2024; 15(9): 882-890</p>
URL	https://www.wjgnet.com/2218-5836/full/v15/i9/882.htm
DOI	https://dx.doi.org/10.5312/wjo.v15.i9.882

Full Article (PDF)	WJO-15-882-with-cover.pdf
PRISMA 2009 Checklist	98609-PRISMA-2009-Checklist.pdf
Manuscript File	98609_Auto_Edited_014259.docx
Answering Reviewers	98609-answering-reviewers.pdf
Audio Core Tip	98609-audio.m4a
Biostatistics Review Certificate	98609-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98609-conflict-of-interest-statement.pdf
Copyright License Agreement	98609-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	98609-non-native-speakers.pdf
Supplementary Material	98609-supplementary-material.pdf
Peer-review Report	98609-peer-reviews.pdf
Scientific Misconduct Check	98609-scientific-misconduct-check.png
Scientific Editor Work List	98609-scientific-editor-work-list.pdf
CrossCheck Report	98609-crosscheck-report.png