| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Hepatitis B core-related antigen as a promising serological marker for monitoring hepatitis B virus cure
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue Qiu, Qiao Tang, Xiao-Qing Liu, Yun-Ling Xue, Yi Zeng and Peng Hu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chongqing Talents Project |
cstc2021ycjh-bgzxm0150 |
| The Remarkable Innovation–Clinical Research Project, The Second Affiliated Hospital of Chongqing Medical University and Scientific |
|
| Technological Research Program of Chongqing Municipal Education Commission, The Second Affiliated Hospital of Chongqing Medical University |
KJZD-K202300404 |
| The First Batch of Key Disciplines on Public Health in Chongqing, The Health Commission of Chongqing |
2022 (72) |
|
| Corresponding Author |
Peng Hu, Professor, Department of Infectious Diseases, Institute for Viral Hepatitis, The Key Laboratory of Molecular Biology for Infectious Diseases, Chinese Ministry of Education, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, Yuzhong District, Chongqing 400010, China. hp_cq@163.com |
| Key Words |
Hepatitis B; Hepatitis B core-related antigen; Hepatitis B surface antigen; Hepatitis B virus DNA; Covalently closed circular DNA; Hepatitis B virus cure |
| Core Tip |
Elimination of hepatitis B virus (HBV) infection by 2030 is a common global goal proposed by the World Health Organization, and the challenge of HBV cure is the persistence of viral replication driven by the ovalently closed circular DNA (cccDNA) pool. Currently, clinical markers of HBV DNA and HBsAg have limited utility in predicting HBV cure, either alone or in combination. In this review, we concentrate on the serum hepatitis B core-related antigen, an emerging serologic marker that correlates well with cccDNA, the continued monitoring of which during long-term therapy may aid in clinical management and facilitate the achievement of a complete cure in patients with chronic hepatitis B. |
| Publish Date |
2025-01-06 08:47 |
| Citation |
<p>Qiu Y, Tang Q, Liu XQ, Xue YL, Zeng Y, Hu P. Hepatitis B core-related antigen as a promising serological marker for monitoring hepatitis B virus cure. <i>World J Hepatol</i> 2025; 17(1): 98658</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i1/98658.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i1.98658 |
