Publication Name	World Journal of Gastroenterology
Manuscript ID	98678
Country	China

Received	2024-07-10 11:48
Peer-Review Started	2024-07-10 11:48
To Make the First Decision
Return for Revision	2024-07-23 10:38
Revised	2024-08-02 16:43
Second Decision	2024-08-19 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-08-19 06:16
Articles in Press	2024-08-19 06:16
Publication Fee Transferred	2024-08-19 13:48
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-08-23 00:10
Publish the Manuscript Online	2024-09-02 03:59

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Pan-immune-inflammation value as a prognostic biomarker for colon cancer and its variation by primary tumor location
Manuscript Source	Unsolicited Manuscript
All Author List	Qian-Yu Wang, Wen-Tao Zhong, Yi Xiao, Guo-Le Lin, Jun-Yang Lu, Lai Xu, Guan-Nan Zhang, Jun-Feng Du and Bin Wu
ORCID	Author(s) ORCID Number Qian-Yu Wang http://orcid.org/0000-0001-7048-8847 Wen-Tao Zhong http://orcid.org/0000-0002-6268-1898 Yi Xiao http://orcid.org/0000-0002-4309-1227 Guo-Le Lin http://orcid.org/0000-0001-6225-3028 Jun-Yang Lu http://orcid.org/0000-0002-0206-621X Lai Xu http://orcid.org/0000-0002-9444-1733 Guan-Nan Zhang http://orcid.org/0000-0001-8685-5015 Jun-Feng Du http://orcid.org/0000-0002-8482-4271 Bin Wu http://orcid.org/0000-0002-5388-2874
Funding Agency and Grant Number	Funding Agency Grant Number National High Level Hospital Clinical Research Funding 2022-PUMCH-B-003
Corresponding Author	Bin Wu, MD, Chief Doctor, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan Road, Wangfujing, Dongcheng District, Beijing 100730, China. wubin@pumch.cn
Key Words	Colon cancer; Left-sided colon cancer; Right-sided colon cancer; Pan-immune-inflammation value; Systemic inflammatory biomarkers; Prognosis
Core Tip	This study underscores the critical role of tumor location in shaping the prognostic significance of the pan-immune-inflammation value in colon cancer patients. The findings reveal that a high pan-immune-inflammation value is strongly correlated with poorer disease-free survival in patients with left-sided colon cancer, while no such association was observed in right-sided colon cancer. These results suggest that integrating tumor location into prognostic evaluations could improve the identification of high-risk patients and facilitate more precise, personalized treatment strategies in clinical practice.
Publish Date	2024-09-02 03:59
Citation	<p>Wang QY, Zhong WT, Xiao Y, Lin GL, Lu JY, Xu L, Zhang GN, Du JF, Wu B. Pan-immune-inflammation value as a prognostic biomarker for colon cancer and its variation by primary tumor location. <i>World J Gastroenterol</i> 2024; 30(33): 3823-3836</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i33/3823.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i33.3823

Full Article (PDF)	WJG-30-3823-with-cover.pdf
STROBE Statement	98678-STROBE-statement.pdf
Manuscript File	98678_Auto_Edited_081137.docx
Answering Reviewers	98678-answering-reviewers.pdf
Audio Core Tip	98678-audio.aac
Biostatistics Review Certificate	98678-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98678-conflict-of-interest-statement.pdf
Copyright License Agreement	98678-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	98678-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	98678-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	98678-non-native-speakers.pdf
Supplementary Material	98678-supplementary-material.pdf
Peer-review Report	98678-peer-reviews.pdf
Scientific Misconduct Check	98678-scientific-misconduct-check.png
Scientific Editor Work List	98678-scientific-editor-work-list.pdf
CrossCheck Report	98678-crosscheck-report.pdf