| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ruo-Yu Guan, Jia-Wei Wu, Zi-Yun Yuan, Zhi-Yuan Liu, Zi-Zhu Liu, Zhi-Cong Xiao, Jing-Hui Li, Cheng-Zhi Huang, Jun-Jiang Wang and Xue-Qing Yao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Leading Innovation Specialist Support Program of Guangdong Province |
|
| Science and Technology Planning Project of Ganzhou |
202101074816 |
| National Natural Science Foundation of China |
82260501 |
|
| Corresponding Author |
Xue-Qing Yao, MD, PhD, Professor, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, No. 106 Zhongshan Er Road, Guangzhou 510080, Guangdong Province, China. syyaoxueqing@scut.edu.cn |
| Key Words |
Colon cancer; Chemoresistance; Diabetes mellitus; Prognosis; Type II diabetes mellitus |
| Core Tip |
Type II diabetes mellitus (T2DM) has been consistently associated with high risk of carcinogenesis in gastrointestinal malignances. However, the relationship between T2DM and postoperative chemotherapy outcomes or long-term prognosis in patients with colon cancer remains unclear. This study emphasizes that preoperative poorly controlled hyperglycemia, but not T2DM history, is associated with enhanced chemoresistance and frustrating prognosis in patients who underwent surgery for stage III colon cancer. Our results also remind us of the importance of managing hyperglycemia in patients with T2DM, and that glycemic-related parameters such as fasting plasma glucose and glycosylated hemoglobin levels are potential predictive indicators for chemotherapy responses. |
| Publish Date |
2024-12-20 03:53 |
| Citation |
<p>Guan RY, Wu JW, Yuan ZY, Liu ZY, Liu ZZ, Xiao ZC, Li JH, Huang CZ, Wang JJ, Yao XQ. Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer. <i>World J Gastroenterol</i> 2025; 31(3): 98688</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i3/98688.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i3.98688 |
