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2/14/2025 10:33:20 AM | Browse: 153 | Download: 644
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Received |
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2024-07-04 03:11 |
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Peer-Review Started |
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2024-07-04 03:11 |
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First Decision by Editorial Office Director |
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2024-11-11 07:24 |
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Return for Revision |
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2024-11-11 07:24 |
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Revised |
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2024-12-11 03:21 |
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Publication Fee Transferred |
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2024-12-18 08:58 |
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Second Decision by Editor |
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2024-12-23 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-12-23 08:11 |
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Articles in Press |
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2024-12-23 08:11 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-01-13 07:04 |
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Publish the Manuscript Online |
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2025-02-14 10:33 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
DNMT1 promotes the proliferation and migration of gastric cancer cells by inducing microRNA-125a-5p methylation to promote SERPINE1 protein
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui Xie, Hui Wang, Ru-Hong Li, Yue-Wen Zhang, Xi-Rui Fan, Xiao-Xue He and Ao-Ran Guan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research Program of the Science and Technology Department of Yunnan Province |
No. 202101AY070001-204 |
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| Corresponding Author |
Ao-Ran Guan, Department of General Surgery, Yan’an Hospital of Kunming City, No. 245 Renmin East Road, Kunming 650051, Yunnan Province, China. guanaoran@126.com |
| Key Words |
Gastric cancer; microRNA-125a-5p; DNA methyltransferase 1; SERPINE1; Methylation |
| Core Tip |
This study revealed the tumor suppressive effect of microRNAs (miR)-125a-5p in gastric cancer (GC) through inhibition of cell proliferation, migration and invasion, and regulation of epithelial-mesenchymal transition related protein expression. The low expression of miR-125a-5p is associated with DNMT1-mediated promoter methylation and is negatively correlated with SERPINE1 expression. This discovery provides a new target for GC therapy. |
| Publish Date |
2025-02-14 10:33 |
| Citation |
Xie H, Wang H, Li RH, Zhang YW, Fan XR, He XX, Guan AR. DNMT1 promotes the proliferation and migration of gastric cancer cells by inducing microRNA-125a-5p methylation to promote SERPINE1 protein. World J Gastrointest Oncol 2025; 17(3): 98703 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i3/98703.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i3.98703 |
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