Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	98703
Country	China

Received	2024-07-04 03:11
Peer-Review Started	2024-07-04 03:11
To Make the First Decision
Return for Revision	2024-11-11 07:24
Revised	2024-12-11 03:21
Second Decision	2024-12-23 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-23 08:11
Articles in Press	2024-12-23 08:11
Publication Fee Transferred	2024-12-18 08:58
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-13 07:04
Publish the Manuscript Online	2025-02-14 10:33

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	DNMT1 promotes the proliferation and migration of gastric cancer cells by inducing microRNA-125a-5p methylation to promote SERPINE1 protein
Manuscript Source	Unsolicited Manuscript
All Author List	Hui Xie, Hui Wang, Ru-Hong Li, Yue-Wen Zhang, Xi-Rui Fan, Xiao-Xue He and Ao-Ran Guan
ORCID	Author(s) ORCID Number Ao-Ran Guan http://orcid.org/0009-0005-2621-8758
Funding Agency and Grant Number	Funding Agency Grant Number Research Program of the Science and Technology Department of Yunnan Province No. 202101AY070001-204
Corresponding Author	Ao-Ran Guan, Department of General Surgery, Yan’an Hospital of Kunming City, No. 245 Renmin East Road, Kunming 650051, Yunnan Province, China. guanaoran@126.com
Key Words	Gastric cancer; microRNA-125a-5p; DNA methyltransferase 1; SERPINE1; Methylation
Core Tip	This study revealed the tumor suppressive effect of microRNAs (miR)-125a-5p in gastric cancer (GC) through inhibition of cell proliferation, migration and invasion, and regulation of epithelial-mesenchymal transition related protein expression. The low expression of miR-125a-5p is associated with DNMT1-mediated promoter methylation and is negatively correlated with SERPINE1 expression. This discovery provides a new target for GC therapy.
Publish Date	2025-02-14 10:33
Citation	<p>Xie H, Wang H, Li RH, Zhang YW, Fan XR, He XX, Guan AR. DNMT1 promotes the proliferation and migration of gastric cancer cells by inducing microRNA-125a-5p methylation to promote SERPINE1 protein. <i>World J Gastrointest Oncol</i> 2025; 17(3): 98703</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i3/98703.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i3.98703

Full Article (PDF)	WJGO-17-98703-with-cover.pdf
Manuscript File	98703_Auto_Edited_101827.docx
Answering Reviewers	98703-answering-reviewers.pdf
Audio Core Tip	98703-audio.mp3
Biostatistics Review Certificate	98703-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98703-conflict-of-interest-statement.pdf
Copyright License Agreement	98703-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98703-foundation-statement.pdf
Institutional Review Board Approval Form or Document	98703-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	98703-non-native-speakers.pdf
Peer-review Report	98703-peer-reviews.pdf
Scientific Misconduct Check	98703-scientific-misconduct-check.png
Scientific Editor Work List	98703-scientific-editor-work-list.pdf
CrossCheck Report	98703-crosscheck-report.png
CrossCheck Report	98703-crosscheck-report.pdf