| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Observational Study |
| Article Title |
Sleep disturbances and psychomotor retardation in the prediction of cognitive impairments in patients with major depressive disorder
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mi Wang, Wen-Tao Chen, Hao-Ting Wang, Bang-Shan Liu, Yu-Meng Ju, Qiang-Li Dong, Xiao-Wen Lu, Jin-Rong Sun, Liang Zhang, Hua Guo, Fu-Tao Zhao, Wei-Hui Li, Li Zhang, Ze-Xuan Li, Mei Liao, Yan Zhang, Jin Liu and Ling-Jiang Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82301738 |
| National Key Research and Development Program of China |
2019YFA0706200 |
| Natural Science Foundation of Hunan Province |
2022JJ40701 and 2022JJ40697 |
|
| Corresponding Author |
Mei Liao, Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. liaomei123@csu.edu.cn |
| Key Words |
Major depressive disorder; Cognitive impairment; Depressive symptoms; Anxiety symptoms; Sleep disturbance; Psychomotor retardation |
| Core Tip |
In this study, four major cognitive domains were assessed in 162 patients with major depressive disorder and 142 healthy controls via a comprehensive cognitive battery. Linear regression analyses and mediation analyses revealed that sleep disturbances independently contributed to executive function, processing speed, and memory, whereas psychomotor retardation (PR) symptoms independently contributed to processing speed. PR symptoms completely mediated the effect of sleep disturbances on processing speed. Psychic anxiety symptoms contributed to impairment in all four cognitive domains. Sleep disturbances mediated the effect of psychic anxiety symptoms on executive function, and PR symptoms mediated the effect of psychic anxiety symptoms on processing speed. |
| Publish Date |
2024-10-17 09:04 |
| Citation |
<p>Wang M, Chen WT, Wang HT, Liu BS, Ju YM, Dong QL, Lu XW, Sun JR, Zhang L, Guo H, Zhao FT, Li WH, Zhang L, Li ZX, Liao M, Zhang Y, Liu J, Li LJ. Sleep disturbances and psychomotor retardation in the prediction of cognitive impairments in patients with major depressive disorder. <i>World J Psychiatry</i> 2024; 14(10): 1474-1483</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v14/i10/1474.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v14.i10.1474 |
