Publication Name	World Journal of Critical Care Medicine
Manuscript ID	98791
Country	Brazil

Received	2024-07-08 13:50
Peer-Review Started	2024-07-05 13:49
To Make the First Decision
Return for Revision	2024-11-26 08:58
Revised	2024-12-11 03:53
Second Decision	2024-12-19 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-19 08:00
Articles in Press	2024-12-19 08:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-08 10:55
Publish the Manuscript Online	2025-02-27 08:55

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Critical Care Medicine
Manuscript Type	Minireviews
Article Title	Why should lymphocytes immune profile matter in sepsis？
Manuscript Source	Invited Manuscript
All Author List	Wagner Nedel, Lílian R Henrique and Luis Valmor Portela
ORCID	Author(s) ORCID Number Wagner Nedel http://orcid.org/0000-0003-2539-4256 Lílian R Henrique http://orcid.org/0000-0002-2430-0118 Luis Valmor Portela http://orcid.org/0000-0001-6113-8466
Funding Agency and Grant Number
Corresponding Author	Wagner Nedel, Assistant Professor, MD, PhD, Department of Intensive Care Unit, Conceição Hospital Group, Francisco Trein 596, Segundo Andar, Porto Alegre 91350200, Brazil. wagnernedel@gmail.com
Key Words	Lymphocytes; Neutrophil-to-lymphocyte ratio; Sepsis; Septic shock; Chronic critical illness; Persistent inflammation, immunosuppression, and catabolism syndrome
Core Tip	Lymphocytes are essential effectors in the immune response to sepsis, contributing to both the initial defense against infection and the regulation of inflammation during the progression to chronic organ failure. One hallmark of sepsis is a profound disruption in lymphocyte homeostasis, that may lead to the development of an immunosuppressive state. Lymphocytes counts and derived variables show significant potential as prognostic markers in sepsis, offering insight into mortality risk and the likelihood of persistent organ dysfunction.
Publish Date	2025-02-27 08:55
Citation	<p>Nedel W, Henrique LR, Portela LV. Why should lymphocytes immune profile matter in sepsis？. <i>World J Crit Care Med</i> 2025; 14(2): 98791</p>
URL	https://www.wjgnet.com/2220-3141/full/v14/i2/98791.htm
DOI	https://dx.doi.org/10.5492/wjccm.v14.i2.98791

Full Article (PDF)	WJCCM-14-98791-with-cover.pdf
Manuscript File	98791_Auto_Edited_033304.docx
Answering Reviewers	98791-answering-reviewers.pdf
Audio Core Tip	98791-audio.mp3
Conflict-of-Interest Disclosure Form	98791-conflict-of-interest-statement.pdf
Copyright License Agreement	98791-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	98791-non-native-speakers.pdf
Peer-review Report	98791-peer-reviews.pdf
Scientific Misconduct Check	98791-scientific-misconduct-check.png
Scientific Editor Work List	98791-scientific-editor-work-list.pdf
CrossCheck Report	98791-crosscheck-report.pdf