BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
1/20/2025 7:38:44 AM | Browse: 87 | Download: 294
 |
Received |
|
2024-08-19 07:39 |
|
Peer-Review Started |
|
2024-07-06 05:20 |
|
First Decision by Editorial Office Director |
|
2024-11-10 04:35 |
|
Return for Revision |
|
2024-11-10 04:35 |
|
Revised |
|
2024-11-19 13:15 |
|
Publication Fee Transferred |
|
2024-11-25 09:42 |
|
Second Decision by Editor |
|
2024-12-25 02:46 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2024-12-25 07:02 |
|
Articles in Press |
|
2024-12-25 07:02 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-01-10 02:59 |
|
Publish the Manuscript Online |
|
2025-01-20 07:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Modified Pulsatilla decoction alleviates 5-fluorouracil-induced intestinal mucositis by modulating the TLR4/MyD88/NF-κB pathway and gut microbiota
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Tong Qiu, Xin-Yi Luo, Ya-Feng Deng, Xue Zheng, Jian-Guo Qiu, Lin-Sheng Zhang, Xiao-Qi Huang, Xue-Bao Zheng and Hai-Yang Huang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic and Applied Basic Research Foundation of Guangdong Province |
2021B1515140043 |
| Basic and Applied Basic Research Foundation of Guangdong Province |
2022A1515140124 |
| Basic and Applied Basic Research Foundation of Guangdong Province |
2023A1515140115 |
|
| Corresponding Author |
Xue-Bao Zheng, PhD, Professor, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, No. 232 East Ring Road, University City, Panyu District, Guangzhou 525000, Guangdong Province, China. xuebaozheng@gzucm.edu.cn |
| Key Words |
Modified Pulsatilla decoction; Intestinal mucositis; Oxidative stress; Gut microbiota, TLR4/MyD88/NF-κB pathway; Inflammatory response |
| Core Tip |
Developing safe and effective drugs for the treatment of intestinal mucositis (IM) is of great significance because IM is a common and severe complication of chemotherapy that can lead to a spectrum of gastrointestinal toxicities and even death. In this study, modified Pulsatilla decoction (PD) demonstrated significant efficacy in alleviating 5-fluorouracil-induced IM in mice. The treatment significantly improved key clinical symptoms, including weight loss, diarrhea, and intestinal damage, through modulation of the TLR4/MyD88/NF-κB pathway and restoration of intestinal microbiota balance. These findings provide a novel scientific foundation for the potential clinical application of modified PD in IM management. |
| Publish Date |
2025-01-20 07:38 |
| Citation |
Qiu YT, Luo XY, Deng YF, Zheng X, Qiu JG, Zhang LS, Huang XQ, Zheng XB, Huang HY. Modified Pulsatilla decoction alleviates 5-fluorouracil-induced intestinal mucositis by modulating the TLR4/MyD88/NF-κB pathway and gut microbiota. World J Gastroenterol 2025; 31(7): 98806
|
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i7/98806.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i7.98806 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
