| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Modified Pulsatilla decoction alleviates 5-fluorouracil-induced intestinal mucositis by modulating the TLR4/MyD88/NF-κB pathway and gut microbiota
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Tong Qiu, Xin-Yi Luo, Ya-Feng Deng, Xue Zheng, Jian-Guo Qiu, Lin-Sheng Zhang, Xiao-Qi Huang, Xue-Bao Zheng and Hai-Yang Huang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic and Applied Basic Research Foundation of Guangdong Province |
2021B1515140043 |
| Basic and Applied Basic Research Foundation of Guangdong Province |
2022A1515140124 |
| Basic and Applied Basic Research Foundation of Guangdong Province |
2023A1515140115 |
|
| Corresponding Author |
Xue-Bao Zheng, PhD, Professor, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, No. 232 East Ring Road, University City, Panyu District, Guangzhou 525000, Guangdong Province, China. xuebaozheng@gzucm.edu.cn |
| Key Words |
Modified Pulsatilla decoction; Intestinal mucositis; Oxidative stress; Gut microbiota, TLR4/MyD88/NF-κB pathway; Inflammatory response |
| Core Tip |
Developing safe and effective drugs for the treatment of intestinal mucositis (IM) is of great significance because IM is a common and severe complication of chemotherapy that can lead to a spectrum of gastrointestinal toxicities and even death. In this study, modified Pulsatilla decoction (PD) demonstrated significant efficacy in alleviating 5-fluorouracil-induced IM in mice. The treatment significantly improved key clinical symptoms, including weight loss, diarrhea, and intestinal damage, through modulation of the TLR4/MyD88/NF-κB pathway and restoration of intestinal microbiota balance. These findings provide a novel scientific foundation for the potential clinical application of modified PD in IM management. |
| Publish Date |
2025-01-20 07:38 |
| Citation |
Qiu YT, Luo XY, Deng YF, Zheng X, Qiu JG, Zhang LS, Huang XQ, Zheng XB, Huang HY. Modified Pulsatilla decoction alleviates 5-fluorouracil-induced intestinal mucositis by modulating the TLR4/MyD88/NF-κB pathway and gut microbiota. World J Gastroenterol 2025; 31(7): 98806 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i7/98806.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i7.98806 |
