| ISSN |
1948-5204 (online) |
| Open Access |
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis via PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ling Wu, Hong-Yao Chen, Jing-Ting Zhang, Ren-Yi Yang, Zhi-Bin Wang, Pei-Sen Xue, Wei Peng, Ke-Xiong Li, Wen-Hui Gao and Pu-Hua Zeng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
82074425 |
| Natural Foundation of Hunan Province |
023JJ30364 and 2023JJ30361 |
| Hunan Provincial Key R&D Program |
2023SK2057 |
| Key Project of Hunan Provincial Administration of Traditional Chinese Medicine |
A2023042 |
|
| Corresponding Author |
Pu-Hua Zeng, MD, PhD, Professor, Cancer Research Institute of Hunan Academy of Traditional Chinese Medicine, Hunan Provincial Hospital of Integrated Traditional Chinese and Western, No. 58 Lushan Road, Yuelu District, Changsha 410006, Hunan Province, China. zph120@126.com |
| Key Words |
Chlorogenic acid; Hepatocellular carcinoma; Ferroptosis; Prostaglandin endoperoxide synthase 2/aldo-keto reductase family 1 member C3/glutathione peroxidase 4 axis; Bioinformatics; In vitro experiment |
| Core Tip |
The study reveals that chlorogenic acid (CGA) dose-dependently inhibits the proliferation, invasion, and migration of hepatocellular carcinoma (HCC) cells. Through bioinformatics analysis and network pharmacology, it is found that CGA induces ferroptosis in HCC cells by regulating the prostaglandin endoperoxide synthase 2/aldo-keto reductase family 1 member C3/glutathione peroxidase 4 signaling pathway, reprogramming arachidonic acid metabolism, and causing mitochondrial damage. This research highlights the potential of CGA as a novel ferroptosis inducer or anti-HCC therapeutic. |
| Publish Date |
2025-02-14 10:33 |
| Citation |
<p>Wu L, Chen HY, Zhang JT, Yang RY, Wang ZB, Xue PS, Peng W, Li KX, Gao WH, Zeng PH. Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis via PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism. <i>World J Gastrointest Oncol</i> 2025; 17(3): 98844</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i3/98844.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i3.98844 |
