Publication Name	World Journal of Gastroenterology
Manuscript ID	98852
Country	China

Received	2024-07-07 16:51
Peer-Review Started	2024-07-07 16:51
To Make the First Decision
Return for Revision	2024-11-16 05:45
Revised	2024-12-08 16:48
Second Decision	2024-12-26 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-26 03:32
Articles in Press	2024-12-26 03:32
Publication Fee Transferred	2024-12-13 09:41
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-09 09:23
Publish the Manuscript Online	2025-01-20 07:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Inhibition of metabotropic glutamate receptor-5 alleviates hepatic steatosis by enhancing autophagy via activation of the AMPK signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Min Tao, Li-Li Zhang, Guang-Hong Zhou, Cong Wang and Xie Luo
ORCID	Author(s) ORCID Number Min Tao http://orcid.org/0000-0001-5804-1671 Li-Li Zhang http://orcid.org/0000-0001-9007-5281 Guang-Hong Zhou http://orcid.org/0000-0001-8775-1998 Cong Wang http://orcid.org/0000-0002-1209-4978 Xie Luo http://orcid.org/0000-0002-4591-3079
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81800771 and 81300702
Corresponding Author	Xie Luo, MD, PhD, Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, No 74 Linjiang Road, Yuzhong District, Chongqing 400010, China. 304408@hospital.cqmu.edu.cn
Key Words	Metabolic dysfunction-associated steatotic liver disease; Hepatic steatosis; Metabotropic glutamate receptor 5; Autophagy
Core Tip	The present work showed that inhibition of metabotropic glutamate receptor 5 can activate the AMPK signaling pathway, promoting the entry of transcription factor EB into the nucleus and enhancing autophagy, which will ameliorate hepatocyte steatosis.
Publish Date	2025-01-20 07:38
Citation	<p>Tao M, Zhang LL, Zhou GH, Wang C, Luo X. Inhibition of metabotropic glutamate receptor-5 alleviates hepatic steatosis by enhancing autophagy via activation of the AMPK signaling pathway. <i>World J Gastroenterol</i> 2025; 31(7): 98852</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i7/98852.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i7.98852

Full Article (PDF)	WJG-31-98852-with-cover.pdf
The ARRIVE Guidelines	98852-The-ARRIVE-Guidelines.pdf
Manuscript File	98852_Auto_Edited_010517.docx
Answering Reviewers	98852-answering-reviewers.pdf
Audio Core Tip	98852-audio.m4a
Biostatistics Review Certificate	98852-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98852-conflict-of-interest-statement.pdf
Copyright License Agreement	98852-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98852-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	98852-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	98852-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	98852-non-native-speakers.pdf
Supplementary Material	98852-supplementary-material.pdf
Peer-review Report	98852-peer-reviews.pdf
Scientific Misconduct Check	98852-scientific-misconduct-check.png
Scientific Editor Work List	98852-scientific-editor-work-list.pdf
CrossCheck Report	98852-crosscheck-report.pdf